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FLASH GENE
Symbol ZNF131 contributors: mct/npt - updated : 29-01-2009
HGNC name zinc finger protein 131
HGNC id 12915
Location 5p12      Physical location : 43.121.641 - 43.175.821
Synonym name zinc finger protein 131 (clone pHZ-10)
Synonym symbol(s) pHZ-10, ZBTB35
DNA
TYPE functioning gene
STRUCTURE 54.20 kb     8 Exon(s)
MAPPING cloned Y linked N status confirmed
Map pter - D5S665 - D5S1958 - ZNF131 - D5S2087 - D5S2063 - cen
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2415 67.2 589 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Nervousbrainforebraincerebral lobeoccipital lobepredominantly
 brainforebraincerebral lobetemporal lobepredominantly
 brainbasal nucleicaudate nucleus predominantly
 brainlimbic systemhippocampus predominantly
 brainhindbraincerebellum predominantly
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BTB (POZ) domain
  • five zinc finger C2H2 type krueppel-like domains
  • three basic regions (BR-1, -2 and -3) (BR-1 and BR-2 are functional nuclear localization signals and as such are designated NLS-1 and NLS-2) (Donaldson 2007)
  • C-terminal region of ZNF131 containing the SUMOylation site is necessary for its inhibition of estrogen signaling
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to rattus Zfp131 (92.5 pc)
    homolog to murine Zfp131 (94.4 pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional regulation (Tommerup 1995)
  • playing a role during development and organogenesis as well as in the function of the adult central nervous system (Trappe 2002)
  • acting as a repressor of ESR1 signaling (Han 2008)
  • is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner ZBTB33
  • inhibits estrogen signaling by acting as an ESR1-co-repressor
  • attenuates estrogen signaling by inhibiting ESR1 homo-dimerization
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacted preferentially with the nuclear import receptor Importin-alpha3 (Donaldson 2007)
  • is a ZBTB33-specific binding partner
  • UHRF2 effectively enhances zinc finger protein 131 (ZNF131) SUMOylation but does not enhance ZNF131 ubiquitination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS