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FLASH GENE
Symbol ZNF10 contributors: mct/npt - updated : 22-01-2010
HGNC name zinc finger protein 10
HGNC id 12879
Location 12q24.33      Physical location : 133.707.213 - 133.736.047
Synonym name zinc finger protein 10 (KOX 1)
Synonym symbol(s) KOX1
DNA
TYPE functioning gene
STRUCTURE 28.83 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC387896 12 LOC387896 LOC387897 12 LOC387897 LOC390370 12 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) SFRS8 12q24.33 splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila) MMP17 12q24.33 matrix metalloproteinase 17 (membrane-inserted) ULK1 12q24.3 unc-51-like kinase 1 (C. elegans) LOC387898 12 LOC387898 PUS1 12q24.33 pseudouridylate synthase 1 EP400 12q24.33 E1A binding protein p400 FLJ33915 12q24.33 hypothetical protein FLJ33915 DDX51 12q24.33 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 MGC3162 12q24.33 hypothetical protein MGC3162 GALNT9 12q24.33 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9) LOC390371 12 similar to proline rich protein 2 P2RX2 12q24.33 purinergic receptor P2X, ligand-gated ion channel, 2 POLE 12q24.3 polymerase (DNA directed), epsilon PXMP2 12q24.33 peroxisomal membrane protein 2, 22kDa MGC5352 12q24.33 hypothetical protein MGC5352 GOLGA3 12q24.33 golgi autoantigen, golgin subfamily a, 3 CHFR 12q24.33 checkpoint with forkhead and ring finger domains LOC90462 12q24.33 hypothetical protein LOC90462 ZNF26 12q24.33 zinc finger protein 26 (KOX 20) ZNF84 12q24.33 zinc finger protein 84 (HPF2) ZNF140 12q24.32-q24.33 zinc finger protein 140 (clone pHZ-39) ZNF10 12q24.33 zinc finger protein 10 (KOX 1) ZNF268 5q11.2-24.3 zinc finger protein 268
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4417 - 573 - Lorenz (2001)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Krüppel associated box (KRAB) N terminal, confering strong transcriptional repressor activity (Lorenz 2001)
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • having a strong transcriptional repressor activity (Lorenz 2001)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+ binding
  • protein
  • interacting with MID1, tripartite RBCC (RING-B box-coiled coil) region (Itokawa 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS