Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZMYND10 contributors: mct/npt - updated : 04-10-2013
HGNC name zinc finger, MYND domain containing 10
HGNC id 19412
Location 3p21.31      Physical location : 50.378.536 - 50.383.156
Synonym name BLU protein
Synonym symbol(s) BLU, FLU, LUCA12
DNA
TYPE functioning gene
STRUCTURE 4.92 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1780 50.21 440 testis and lung 2004 15122337
- - - - - testis and lung 2013 33891471
differing across 35 centrally positioned amino acids
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivefemale systemuteruscervix  
 male systemtestis    Homo sapiens
Respiratorylung     Homo sapiens
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryciliari cell Homo sapiens
cell lineage
cell lines lung cancer cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one VWFC domain
  • one MYND-type zinc finger
  • LxxLL motifs
  • a C-terminal fragment that extends beyond the MYND domain is necessary for interaction between ZMYND10 and LRRC6
  • mono polymer trimer
    HOMOLOGY
    interspecies ortholog to rattus zmynd10
    ortholog to murine Zmynd10
    Homologene
    FAMILY
  • fibrillar collagen family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • localizes to cytoplasmic puncta in respiratory epithelial cells
  • basic FUNCTION
  • stress-responsive gene, candidate tumor suppressor
  • playing a possible role in the development of esophageal squamous cell carcinomas
  • can functionally suppress tumor formation and is, therefore, likely to be one of the candidate tumor suppressor genes involved in nasopharyngeal carcinoma
  • tumor suppressor that acts as a transcriptional regulator through the association with cellular components
  • can mediate the pro-apoptotic activity through the induction of SMEK1
  • act as a tumor suppressor, inhibits clonogenic growth of nasopharyngeal carcinoma cells, arrests the cell cycle at the G1 phase, downregulates JNK (c-Jun N-terminal kinase) and CCND1 promoter activities, and inhibits phosphorylation of JUN
  • cytoplasmic protein required for inner dynein arms (IDAs) and outer dynein arms (ODAs) assembly
  • its expression correlated exclusively with the development of cells with flagella or motile cilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • directly interacts with SMEK1, a regulatory subunit of protein phosphatase 4 (N-terminus of ZMYND10 was observed to interact with the C-terminal of SMEK1)
  • ZMYND10 and LRRC6 interact
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    and inversely correlated with promoter hypermethylation in nasopharyngeal carcinoma
    tumoral     --low  
    in some esophageal squamous cell carcinomas
    tumoral     --low  
    by promoter hypermethylation frequently in myelodysplastic syndrom (MDS) cases, especially in higher risk MDS cases
    tumoral     --low  
    in hepatocellular carcinoma by hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS