Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZMYM2 contributors: mct - updated : 16-10-2017
HGNC name zinc finger, MYM-type 2
HGNC id 12989
Corresponding disease
CAKUT4S congenital anomalies of the kidney and urinary tract-4, syndromic
SCLLS stem-cell leukemia/lymphoma syndrome
Location 13q12.11      Physical location : 20.532.809 - 20.665.967
Synonym name
  • fused in myeloproliferative disorder
  • rearranged in an atypical myeloproliferative disorder
  • zinc finger protein 198
    • Synonym symbol(s) FIM, RAMP, ZNF198, MYM, SCLL
    DNA
    TYPE functioning gene
    STRUCTURE 131.70 kb     26 Exon(s)
    MAPPING cloned Y linked   status confirmed
    Map cen - D13S1316 - ZMYM2 - D13S175 - GJB2 - FGF9 - D13S292 - COL4A1 - D13S283 - qter
    Authors Macdonald (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 5217 154.9 1377 - 2015 26283374
    - - splicing 5170 154.9 1377 - 2015 26283374
    26 - 7424 - 1290 - 2015 26283374
    25 - 7426 - 1377 - 2015 26283374
    25 - 7384 - 1377 - 2015 26283374
    25 - 7340 - 1377 - 2015 26283374
    25 - 7547 - 1377 - 2015 26283374
    26 - 7476 - 1377 - 2015 26283374
    25 - 7429 - 1377 - 2015 26283374
    27 - 7227 - 1312 - 2015 26283374
    27 - 7587 - 1377 - 2015 26283374
    22 - 3920 - 1159 - 2015 26283374
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cysteine-rich region comprising five tandem Cys-X2 repeats corresponding to a novel zinc finger motif
  • ten MYM, myeloproliferative and mental retardation motifs
  • a highly hydrophobic, proline-rich stretch and a putative bipartite nuclear localization signal (NLS)
    • conjugated MetalloP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Zfp198
    intraspecies homolog to DXS6673E,highly
    Homologene
    FAMILY
  • zinc finger protein family
  • MYM subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • transcriptional regulator, involved in the DNA repair process through its interaction with UBE2A, UBE2B and RAD18
  • SUMO-binding activity of the MYM-type zinc fingers in ZMYM2 and ZMYM3
  • having multi-SUMO-binding activity required for its recruitment to chromatin
  • likely a central role for ZMYM2 in the transcriptional regulation of the undifferentiated state and in the exit-from-pluripotency of humanembryonic stem cell (ESC)
  • is a component of a transcriptional corepressor complex recently linked to the silencing of developmentally regulated endogenous retrovirus elements
  • ZMYM2 plays critical roles in kidney and craniofacial development
    • CELLULAR PROCESS nucleotide, repair
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a histone deacetylase complex containing HDAC1, HDAC2, AOF2, RCOR1, ZNF261, KIAA0182 and GTF2I
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • UBE2A
  • UBE2B
  • RAD18
  • forms part of a transcriptional complex acting as a corepressor by interacting with different nuclear receptors, and the LSD1-CoREST-HDAC1 complex on chromatin
  • ZMYM2, ZMYM3, MYM-type zinc fingers interact with the same surface on SUMO-2 recognized by the archetypal consensus SIM
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCLLS , CAKUT4S
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ZMYM2-FGFR1 fusion in myeloproliferative syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS