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FLASH GENE
Symbol ZMAT3 contributors: mct/npt - updated : 11-06-2010
HGNC name zinc finger, matrin type 3
HGNC id 29983
Location 3q26.32      Physical location : 178.735.010 - 178.789.656
Synonym name
  • P53 target zinc finger protein
  • zinc finger protein WIG-1
  • WIG-1/PAG608 protein
  • wildtype p53-induced gene
  • Synonym symbol(s) WIG-1, PAG608, FLJ12296, MGC10613, WIG1
    DNA
    TYPE functioning gene
    STRUCTURE 48.06 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 2432 32 289 - Hellborg (2001)
    6 splicing 2323 32 288 - Hellborg (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systembreastmammary gland  
     male systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three zinc finger domain
  • one nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to murine Wig1
    Homologene
    FAMILY
  • zinc finger protein superfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the TP53-dependent growth regulatory pathway
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TP53 (target of TP53)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in primary squamous cell carcinoma of the lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS