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FLASH GENE
Symbol ZKSCAN4 contributors: mlc - updated : 24-11-2007
HGNC name zinc finger with KRAB and SCAN domains
HGNC id 13854
Location 6p21.33-p21.31      Physical location : 28.212.489 - 28.220.002
Synonym name
  • hypothetical protein P1 p373c6
  • p373c6.1 (novel C2H2 type zinc finger protein)
  • zinc finger protein 307
  • Synonym symbol(s) P1P373C6, ZNF307, FLJ32136
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 7.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2307 61.6 545 - Mungall (2003)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunetonsils    
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix  
     male systemtestis   
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text heart, brain, skeletal muscle, small intestine, and liver tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven C2H2-type zinc fingers
  • one KRAB domain
  • one SCAN box domain
  • an LER domain
  • HOMOLOGY
    Homologene
    FAMILY krüppel C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing TP53 degradation
  • transcriptional repressor that inhibits p53 and p21 transcriptional activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS