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FLASH GENE
Symbol ZKSCAN3 contributors: mct/pgu - updated : 23-09-2010
HGNC name zinc finger with KRAB and SCAN domains 3
HGNC id 13853
Location 6p22.1      Physical location : 28.317.690 - 28.334.523
Synonym name
  • zinc finger protein 306
  • zinc finger protein 309
  • zinc finger protein 47 homolog
  • zinc finger and SCAN domain-containing protein 13
    • Synonym symbol(s) ZF47, ZFP47, ZNF306, dJ874C20.1, ZSCAN13, KIAA0426, FLJ33906, ZNF309
    DNA
    TYPE functioning gene
    STRUCTURE 19.26 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4725 60 538 - 2008 18519692
    7 - 4842 60 538 - 2008 18519692
    5 - 4261 - 390 - 2008 18519692
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KRAB Krüppel-associated box at the N terminus
  • a SCAN box mediating self-association and oligomerization
  • a C2H2 Krüppel-type zinc finger domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila cg4971
    homolog to C.elegans cwn-2
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential transcriptional regulator
  • regulates the expression of several genes favoring tumor progression including integrin beta 4
  • its induction represents a mechanism by which myeloma cells can induce cyclin D2 dysregulation, and contribute to disease pathogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • specifically bind to oligonucleotides representing sequences from the CCND2 promoter, and to the endogenous promoter itself in myeloma cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS