Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZHX3 contributors: mct/npt - updated : 26-05-2020
HGNC name zinc fingers and homeoboxes 3
HGNC id 15935
Location 20q12      Physical location : 39.807.088 - 39.928.739
Synonym name
  • related to mouse homeotic protein ZHX1, 60kDa
  • triple homeobox 1
  • Synonym symbol(s) KIAA0395, TIX1
    DNA
    TYPE functioning gene
    STRUCTURE 139.20 kb     4 Exon(s)
    regulatory sequence Promoter
    text structure bound to the CdxA binding motif
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 10006 104.5 956 - 2006 17056598
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two C2H2-type zinc fingers
  • five homeodomains (HDs) as well as ZHX1
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Zhx3 (84 pc)
    intraspecies paralog to ZHX1
    paralog to ZHX2
    Homologene
    FAMILY
  • zinc fingers and homeoboxes (ZHX) gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text mostly sequestered in the non-nuclear compartment in the normal podocyte by virtue of heterodimer formation, and loss of heterodimerization was associated with entry into the nucleus
    basic FUNCTION
  • major transcriptional mediator of podocyte disease
  • having a transcriptional repressor activity
  • ZHX2 and ZHX3 were involved in the transcriptional repression of the hepatocellular cacinoma markers in normal hepatocytes, suggesting that the failure of the ZHX2 and/or ZHX3 expression might be a critical factor in the hepatocellular carcinogenesis
  • ZHX1, ZHX2, ZHX3 have biological roles in cell cycle control by acting as co-repressors of the transcriptional regulator Nuclear Factor Y
  • is involved in the switch from the undifferentiated state of mesenchymal stem cells (MSC) to an osteogenic program
  • podocyte ZHX2 imbalance is a critical factor in glomerular disease, with minimal change disease disparities mediated mostly through ZHX1, and focal segmental glomerulosclerosis deviations through ZHX3 and ZHX2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizes with both ZHX1 and ZHX2
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with the activation domain of the NF-YA
  • able to form a heterodimer with ZHX2 via a region containing each HD1(homeodomain)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in nephrotic syndrome prior to the onset of proteinuria, and recovery of expression was associated with migration of ZHX3 protein into the nucleus and the development of proteinuria
    tumoral     --low  
    in clear cell Renal cell carcinoma (RCC), significantly associated with pathological stage
    tumoral     --over  
    high mRNA levels of ZHX2 and ZHX3 correlated with better overall survival in patients with breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be useful as an early osteogenic differentiation marker
  • ZHX3 expression may serve as an independent high-risk prognostic predictor
  • Therapy target
    ANIMAL & CELL MODELS