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FLASH GENE
Symbol ZHX3 contributors: mct/npt - updated : 17/11/2008
HGNC name zinc fingers and homeoboxes 3
HGNC id 15935
Location 20q12      Physical location : 39.807.088 - 39.928.739
Synonym name
  • related to mouse homeotic protein ZHX1, 60kDa
  • triple homeobox 1
  • Synonym symbol(s) KIAA0395, TIX1
    DNA
    TYPE functioning gene
    STRUCTURE 121.85 kb     4 Exon(s)
    regulatory sequence Promoter
    text structure bound to the CdxA binding motif
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 9991 104.5 956 - Liu (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two C2H2-type zinc fingers
  • five homeodomains (HDs) as well as ZHX1
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Zhx3 (84 pc)
    intraspecies paralog to ZHX1
    Homologene
    FAMILY
  • zinc fingers and homeoboxes (ZHX) gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text mostly sequestered in the non-nuclear compartment in the normal podocyte by virtue of heterodimer formation, and loss of heterodimerization was associated with entry into the nucleus
    basic FUNCTION
  • major transcriptional mediator of podocyte disease
  • having a transcriptional repressor activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizes with both ZHX1 and ZHX2
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with the activation domain of the NF-YA
  • able to form a heterodimer with ZHX2 via a region containing each HD1(homeodomain)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in nephrotic syndrome prior to the onset of proteinuria, and recovery of expression was associated with migration of ZHX3 protein into the nucleus and the development of proteinuria
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS