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FLASH GENE
Symbol ZHX2 contributors: mct/npt/pgu - updated : 12-07-2013
HGNC name zinc fingers and homeoboxes 2
HGNC id 18513
Location 8q24.13      Physical location : 123.793.900 - 123.986.755
Synonym name
  • transcription factor ZHX2
  • alpha-fetoprotein regulator 1
  • zinc finger and homeodomain protein 2
  • Synonym symbol(s) AFR1, KIAA0854, RAF
    DNA
    TYPE functioning gene
    STRUCTURE 192.85 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPL13 8q22.1-q22.3 mitochondrial ribosomal protein L13 MTBP 8q24.1-q24.2 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa SNTB1 8q24.13 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) HAS2 8q24.13 hyaluronan synthase 2 MRPS36P3 8q24.13 mitochondrial ribosomal protein S36 pseudogene LOC389683 8 LOC389683 LOC392265 8 similar to Cell division protein kinase 5 (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine protein kinase PSSALRE) LOC389684 8 LOC389684 ZHX2 8q24.13 zinc fingers and homeoboxes 2 MGC3067 8q24.13 hypothetical protein MGC3067 MGC21654 8q24.13 unknown MGC21654 product MGC14128 8q24.13 hypothetical protein MGC14128 FLJ14825 8q24.13 hypothetical protein FLJ14825 ZHX1 8q zinc-fingers and homeoboxes 1 LOC392266 8 similar to Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) PRO2000 8p22 similar to Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) LOC392267 8 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 FLJ10204 8q24.13 hypothetical protein FLJ10204 FBXO32 8q24.13 F-box only protein 32 LOC340359 8q24.13 similar to hypothetical protein 8230402K04 ANXA13 8q24.13-q24.2 annexin A13 FLJ23790 8q24.13 hypothetical protein FLJ23790 FLJ35721 8q24.13 hypothetical protein FLJ35721 FLJ32770 8q24.13 hypothetical protein FLJ32770 LOC392268 8 similar to neuropilin- and tolloid-like protein 2 precursor LOC157378 8q24.13 hypothetical protein BC017881 LOC392269 8 similar to Transcription factor SOX-2 FLJ20772 8q24.13 hypothetical protein FLJ20772 RNF139 8q24.1 ring finger 139 CDA11 8q24.13 CDA11 protein NDUFB9 8q24.21 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa MTSS1 8q22.3-q24.13 metastasis suppressor 1 LOC392270 8 similar to MRS2-like, magnesium homeostasis factor FLJ38002 8q24.13 hypothetical protein FLJ38002 SQLE 8q24.1 squalene epoxidase KIAA0196 8q24.1-q24.3 Homo sapiens KIAA0196 gene product (KIAA0196), mRNA.
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4373 92.2 837 - 2003 12741956
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrainforebraincerebral cortex   Homo sapiensFetal
    Urinarykidney    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Cys(2)-His(2)-type zinc-finger motifs
  • five homeodomains (HDs)
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Zhx2
    homolog to murine Zhx2
    Homologene
    FAMILY
  • ZHX family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • having transcription factor activity
  • regulate podocyte gene expression during the development of nephrotic syndrome
  • ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer
  • may participate in globin regulation and may be important in the normal physiology of erythrocytes
  • acts as a transcriptional repressor in cell, and its repressor activity is enhanced by coexpression of an EFNB1 intracellular domain
  • functions as a novel developmental regulator of key genes influencing lipoprotein metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form homodimers but heterodimers with ZHX1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • able to form a heterodimer with ZHX3 via a region containing each HD1(homeodomain)
  • binds to the cytoplasmic domain of EFNB1, which is expressed in cortical neural progenitors and plays a role in neural progenitor cell maintenance
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma
    tumoral   translocation    
    aberration with recurrent breakpoints in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which activate PDE5A and repress ZHX2, deregulating apoptosis, differentiation, and STAT1-signaling in HL cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS