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FLASH GENE
Symbol ZHX1 contributors: mct - updated : 26-05-2020
HGNC name zinc-fingers and homeoboxes 1
HGNC id 12871
Location 8q24.13      Physical location : 124.260.696 - 124.286.547
Synonym name zinc finger and homeodomain protein 1
DNA
TYPE functioning gene
STRUCTURE 27.09 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text with two alternatively spliced isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 5234 - 873 ubiquitous 2009 19348505
4 splicing 4899 - 873 ubiquitous 2009 19348505
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth   highly
Nervousbrain   highly
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea  highly
Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal zinc fingers
  • five central and C-terminal homeo (helix-turn-helix) domains
  • a C-terminal acidic region and two putative nuclear localization signals
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Zhx1
    intraspecies paralog to ZHX3
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional repressor
  • may play like a bridging molecule between DNMT3B
  • and other co-repressor protein
  • enhancing the transcriptional repression mediated by DNMT3B when DNMT3B is directly targeted to DNA
  • ZHX1, ZHX2, ZHX3 have biological roles in cell cycle control by acting as co-repressors of the transcriptional regulator Nuclear Factor Y
  • nuclear transcription repressor known to be involved in cell differentiation and tumorigenesis
  • plays crucial roles in the progression of glioblastoma
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms heterodimers with ZHX3 which is a prerequisite for repressor activity and with ZHX2
  • universal repressor complex containing DNMT3B and
  • ZHX1
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding to the nuclear transcription factor NF-Y
  • interacting with NFYA
  • homeobox domains of ZHX1 interact with the PWWP
  • domain of DNMT3B
  • ZHX1 interact with the activation domain of the nuclear factor Y subunit A (NFYA) and to have a transcriptional repression activity
  • could contribute to glioblastoma progression via the regulations of TWIST1 and SNAI2
  • podocyte ZHX2 imbalance is a critical factor in glomerular disease, with minimal change disease disparities mediated mostly through ZHX1, and focal segmental glomerulosclerosis deviations through ZHX3 and ZHX2
  • cell & other
    REGULATION
    Other SUMOylation of ZHX1 regulated the stability, ubiquitination and transcriptional activity of ZHX1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in clear cell Renal cell carcinoma (RCC), associated with poorer survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • it is an independent prognostic marker in clear cell Renal Cell Carcinoma (ccRCC)
  • potential prognostic maker of glioblastoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    as a potential target for the treatment of Cholangiocarcinoma
    cancerbrain 
    therapeutic target of glioblastoma
    ANIMAL & CELL MODELS