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FLASH GENE
Symbol ZGPAT contributors: mct - updated : 27-08-2010
HGNC name zinc finger, CCCH-type with G patch domain
HGNC id 15948
Location 20q13.33      Physical location : 62.338.793 - 62.367.493
Synonym name G patch domain-containing protein 6
Synonym symbol(s) MGC44880, FLJ14972, ZC3HDC9, KIAA1847, ZIP, ZC3H9, GPATC6, GPATCH6, dJ583P15.3
DNA
TYPE functioning gene
STRUCTURE 28.70 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2017 57.4 531 - Yu (2010)
  • isoform a
  • 7 splicing 1898 55.5 511 - Yu (2010)
  • isoform c
  • 7 splicing 1925 55.5 511 - Yu (2010)
  • isoform c
  • 5 - 868 20.7 188 in the liver and kidneys Yu (2010)
  • lacks exons 24 and part of exon 5, with G-patch domain, the nuclear localization signal, and the C-terminal coiled-coil domain
  • also localized in the nucleus, suggesting that sZIP may function, similar to ZIP, primarily in the nucleus
  • potentially acting to antagonize the transcription repression activity of ZGPAT
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta    
     thyroid    
    Nervousbrain    
    Reproductivefemale systemuterus   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CCCH or C3H1 type zinc finger domain, to recognize a specific DNA sequence
  • a Tudor domain
  • a G-patch domain
  • a coiled-coil domain to recruit the NuRD complex
  • and a nuclear localization signal
  • HOMOLOGY
    interspecies homolog to murine Zgpat (80.9pc)
    homolog to rattus Zgpat (80.0pc)
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • primarily localized in the nucleus (Li 2010)
  • basic FUNCTION
  • acting as a mediator of cellular transformation
  • recruiting the NuRD complex to EGFR promoter and represses EGFR transcription (Li 2009)
  • inhibits cell proliferation and supresses breast carcinogenesis (Li 2009)
  • transcription repressor and potential tumor suppressor (Li 2009)
  • functions as a transcription repressor (Yu 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS