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FLASH GENE
Symbol ZFYVE19 contributors: mct - updated : 23-09-2014
HGNC name zinc finger, FYVE domain containing 19
HGNC id 20758
Location 15q15.1      Physical location : 41.099.273 - 41.106.767
Synonym name
  • MLL partner containing FYVE domain
  • Abscission/NoCut Checkpoint Regulator
  • Synonym symbol(s) FLJ14840, MPFYVE, ANCHR
    DNA
    TYPE functioning gene
    STRUCTURE 7.49 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located 170 kb telomericto AF15q14
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2293 - 471 - 2003 12618766
    10 - 2089 - 403 - 2003 12618766
    11 - 2096 - 296 - 2003 12618766
    12 - 1962 - 461 - 2003 12618766
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     female systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a FYVE-type zinc finger domain
    HOMOLOGY
    interspecies ortholog to murine Zfyve19
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • ubiquitin protein ligase activity
  • involved in regulation of transcription, DNA-dependent
  • key regulator of the abscission checkpoint, functioning through the most downstream component of the ESCRT machinery, the ATPase VPS4A
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • abscission checkpoint is mediated by ZFYVE19 and CHMP4C through retention of VPS4A at the midbody ring
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with MLL gene in a patient with AML-M2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS