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FLASH GENE
Symbol ZFYVE16 contributors: mct/npt - updated : 05-06-2019
HGNC name zinc finger, FYVE domain containing 16
HGNC id 20756
Location 5q14.1      Physical location : 79.703.837 - 79.775.497
Synonym name
  • cDNA sequence,expressed in brain, >100kDa, related to C elegans cosmid D1022
  • endosome-associated FYVE-domain protein
  • protein phosphatase 1, regulatory subunit 69
  • Synonym symbol(s) KIAA0305, ENDOFIN, DKFZp686E13162, PPP1R69
    DNA
    TYPE functioning gene
    STRUCTURE 75.76 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D5S682 - D5S2451 - ZFYVE16 - D5S1437 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 10751 - 1539 - 2010 19887107
    19 - 10944 - 1539 - 2010 19887107
    19 - 10866 - 1539 - 2010 19887107
    19 - 10805 - 1539 - 2010 19887107
    4 - 2892 - 809 - 2010 19887107
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain    
     spinal cord    
    Urinarybladder   highly
    Visualeyeretina   
     eyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • FYVE zinc finger
  • a protein-phosphatase-binding motif, which functions to negatively modulate BMP signals through receptor dephosphorylation
  • C-terminal half is responsible for interaction with the C-terminal region of TOM1 and for recruitment of TOM1 and clathrin to endosomes
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid D1022
    intraspecies homolog to SARA1
    Homologene
    FAMILY FYVE-domain protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a potential roles in regulating membrane traffic
  • facilitates TGF- signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing SMAD4 to the proximity of the receptor complex
  • plays an important role in both positive and negative feedback regulation of the BMP signaling pathway, acting a SMAD anchor for receptor activation in BMP signaling
  • plays an important role in both positive and negative feedback regulation of the BMP signaling pathway (Shi 2007)
  • endosome-associated FYVE-domain protein endofin which acts as a Smad anchor for receptor activation in BMP signaling (Shi 2007)
  • possible role of Endofin in the modulation of MAPK pathway
  • is involved in endosomal trafficking and in TGFB1, BMP, and EGFR signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeted to early endosomes by its FYVE domain and colocalized with SARA1
  • interacting with TOM1
  • modulates hepcidin through BMP-SMAD signalling
  • ZFYVE16 binds to SMAD4 and their binding affects the formation of SMAD2/3-SMAD4 complex in TGFB1 signaling
  • ZFYVE9, ZFYVE16 recruit the tumor supressor PTPN23, a master regulator of endosomal sorting and ESCRT-dependent receptor downregulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS