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FLASH GENE
Symbol ZFYVE1 contributors: mct - updated : 23-03-2016
HGNC name zinc finger, FYVE domain containing 1
HGNC id 13180
Location 14q24.2      Physical location : 73.436.159 - 73.493.920
Synonym name
  • double fyve-containing protein 1
  • zinc finger protein, subfamily 2A (FYVE domain containing), 1
  • tandem FYVE fingers-1
  • Synonym symbol(s) DFCP1, TAFF1, KIAA1589, ZNFN2A1, SR3, DFCP1, PPP1R172
    DNA
    TYPE functioning gene
    STRUCTURE 57.77 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4405 - 777 - 2001 11739631
    9 - 2627 - 362 - 2001 11739631
    12 - 4463 - 763 - 2001 11739631
    9 - 2641 - 362 - 2001 11739631
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunespleen    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal C2H2 zinc finger motifs
  • ER-targeting motif is necessary and sufficient for ER targeting but insufficient for omegasome targeting
  • two C terminal zinc binding FYVVE domains
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc fingers family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • in nutrient-rich conditions, localizes to the ER membrane ubiquitously and to the Golgi apparatus, but autophagy is not induced
  • GFP-ZFYVE1 has been shown to localize to the omegasome
  • basic FUNCTION
  • potentially involved in cellular trafficking
  • is an indicator of the phagophore-associated PtdIns(3)P-enriched membrane formation from the endoplasmic reticulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphatidyl inositol 3 phosphate binding protein
  • TRIM13 interacts with p62/SQSTM1 and co-localizes with ZFYVE1
  • actin filaments colocalized with ATG14, BECN1/Beclin1 and PtdIns3P-rich structures, and some of them have a typical omegasome shape stained with the double FYVE domain or ZFYVE1
  • EMC6 interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1
  • DACT1 increases autophagosome formation as indicated by elevated puncta formation of MAP1LC3A, ATG14 and ZFYVE1 (Double FYVE-containing protein 1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS