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FLASH GENE
Symbol ZFP90 contributors: mct - updated : 19-06-2009
HGNC name zinc finger protein 90 homolog (mouse)
HGNC id 23329
Corresponding disease
SPOAN spastic paraplegia, congenital optic atrophy, neuropathy
Location 16q22.1      Physical location : 68.573.660 - 68.601.038
Synonym name zinc finger protein 476
Synonym symbol(s) KIAA1954, NK10, ZNF756
DNA
TYPE functioning gene
STRUCTURE 27.38 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LCAT 16q22.1 lecithin-cholesterol acyltransferase SLC12A4 16q22.1 solute carrier family 12 (potassium/chloride transporters), member 4 DPEP3 16q22.1 dipeptidase 3 DPEP2 16q22.1 dipeptidase 2 LOC339065 16q22.1 similar to putative membrane-bound dipeptidase-2 DDX28 16q22.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 FLJ20399 16q22.1 hypothetical protein FLJ20399 NFATC3 16q22.1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 FLJ21918 16q22.1 hypothetical protein FLJ21918 LYPLA3 16q22.1 lysophospholipase 3 (lysosomal phospholipase A2) SLC7A6 16q22.1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 FLJ13291 16q22.1 hypothetical protein FLJ13291 FLJ10640 16q22.1 hypothetical protein FLJ10640 FLJ22593 16q22.1 hypothetical protein FLJ22593 SMPD3 16q22.2 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) ZFP90 16q22.1 zinc finger protein 90 homolog (mouse) CDH3 16q22.1 cadherin 3, type 1, P-cadherin (placental) CDH1 16q22.1 cadherin 1, type 1, E-cadherin (epithelial) FLJ12331 16q22.1 hypothetical protein FLJ12331
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4384 - 636 - Lange (1995)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrineparathyroid   highly
Gustatory (taste)tongue    
Lymphoid/Immunelymph node   highly
 spleen   highly
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 C2H2-type zinc fingers
  • a KRAB domain exhibiting repressing activity, repressor domain derived from the proteins Egr-1, Oct2A and Dr1 (Thiel 2001)
  • individual domains differentially contributing to zinc-dependent target DNA binding (Lange 1995)
  • HOMOLOGY
    Homologene
    FAMILY Krueppel C2H2-type zinc finger protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function as a repressor or silencer protein , and most likely exerts its repressing activity upon
  • zinc-dependent binding to DNA
  • may be involved in proper spermatogenesis by
  • repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid
    cell state
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPOAN
    Susceptibility To colorectal cancer (CRC)
    Variant & Polymorphism SNP
  • 23 SNPs associated with CRC
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS