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FLASH GENE
Symbol ZFP64 contributors: mct - updated : 10-11-2010
HGNC name zinc finger protein 64 homolog (mouse)
HGNC id 15940
Location 20q13.2      Physical location : 50.700.550 - 50.808.524
Synonym name zinc finger protein 338
Synonym symbol(s) FLJ10734, ZNF338, dJ831D17.1, FLJ12628, dJ548G19.1, MGC940, Zfp-64
DNA
TYPE functioning gene
STRUCTURE 107.98 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RPL36P2 20q13.1 ribosomal protein L36 pseudogene 2 PARD6B 20q13.13 par-6 partitioning defective 6 homolog beta (C. elegans) BCAS4 20q13.13-q13.2 breast carcinoma amplified sequence 4 TMSL6 20 thymosin-like 6 ADNP 20q13.3-q13.2 activity-dependent neuroprotector PSMD10P 20q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene DPM1 20q13.13 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit MOCS3 20 molybdenum cofactor synthesis 3 KCNG1 20q13 potassium voltage-gated channel, subfamily G, member 1 LAMR1P1 20q13.3 laminin receptor 1 pseudogene 1 NFATC2 20q13.2-q13.31 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 ATP9A 20q13.1-q13.2 ATPase, class II, type 9A SALL4 20q13.13-q13.2 sal-like 4 (Drosophila) ERP28P 20q13.13 endoplasmic reticulum lumenal protein 28 pseudogene ZFP64 20q13.13 zinc finger protein 64 homolog (mouse) MRPS33P4 20q13.13 mitochondrial ribosomal protein S33 pseudogene 4 RPL36P1 20q13 ribosomal protein L36 pseudogene 1 C20orf17 20q13.2 chromosome 20 open reading frame 17 PPIAL2 20q13.2-q13.3 peptidylprolyl isomerase A (cyclophilin A)-like 2 ZNF217 20q13.2 zinc finger protein 217
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 3281 74.6 681 - 1997 9034307
also called isoform a
5 - 3119 68.6 627 - 1997 9034307
also called isoform b
6 - 3275 74.5 679 - 1997 9034307
also called isoform c
9 - 2967 72.2 645 - 1997 9034307
also called isoform d
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten zinc finger motifs of the C2H2 Kruppel type
  • multiple phosphorylation sites
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Zfp36
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • coactivator of NOTCH1, and potentialy mediates mesenchymal cell differentiation by modulating NOTCH1 signaling
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    ZN2+ binding
    protein
  • associated with the intracellular domain of NOTCH1, recruited to the promoters of the NOTCH1 target genes HES1 and HEY1, and transactivates them
  • downstream target of RUNX2
  • cell & other
    REGULATION
    Other regulated by RUNX2 (expression under the control of RUNX2, and is upregulated by direct transactivation of its promoter)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS