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FLASH GENE
Symbol ZFP36L2 contributors: mct/npt - updated : 03-07-2008
HGNC name zinc finger protein 36, C3H type-like 2
HGNC id 1108
Location 2p22.3      Physical location : 43.449.541 - 43.453.745
Synonym name
  • butyrate response factor 2 early response gene (TIS)
  • EGF-response factor 2
  • protein TIS11D
  • Synonym symbol(s) TIS11D, ERF2, BRF2, EVI134, TISD, ERF-2, RNF162C
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391369 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC284397 2p22.1 similar to FKSG60 LOC391370 2 similar to ribosomal protein S12 LOC388942 2 hypothetical gene supported by AK126414 LOC285047 2p22.1 hypothetical LOC285047 LOC91461 2p22.1 hypothetical protein BC007901 EML4 2p22-p21 echinoderm microtubule associated protein like 4 COX7A2L 2p22.1-p16 cytochrome c oxidase subunit VIIa polypeptide 2 like LOC253584 2p22.1 hypothetical LOC253584 KCNG3 2p22.1 potassium voltage-gated channel, subfamily G, member 3 MTA3 2p21 potassium voltage-gated channel, subfamily G, member 3 TG1019 2p22.1 G-protein coupled receptor TG1019 HAAO 2p21 3-hydroxyanthranilate 3,4-dioxygenase LOC388943 2 similar to cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 ZFP36L2 2p22.3 zinc finger protein 36, C3H type-like 2 MGC40574 2p22.1 hypothetical protein MGC40574 THADA 2p22.1 thyroid adenoma associated KIAA2028 2p22.1 similar to PH (pleckstrin homology) domain D2LIC 2p25.1-p24.1 dynein 2 light intermediate chain ABCG5 2p21 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) ABCG8 2p21 ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) LRPPRC 2p21 leucine-rich PPR-motif containing PPM1B 2p22,1 protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform LOC391371 2 similar to 60S RIBOSOMAL PROTEIN L12 SLC3A1 2p16.3 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 FLJ23451 2p22.1 hypothetical protein FLJ23451 SIX3 2p21-p16 sine oculis homeobox homolog 3 (Drosophila) LOC388944 2 LOC388944 SIX2 2p16-p15 sine oculis homeobox homolog 2 (Drosophila) LOC151111 2p21 hypothetical LOC151111
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3702 51.06 494 - Jackson (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestine   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a distinguishing putative zinc finger domain
  • a repeating Cys-His motif (two C3H1-type zinc fingers)
  • a tandem zinc finger (TZF) domain binding to the class II AU-rich element (ARE) in the 3' untranslated region (3' UTR) of target mRNAs and promotes their deadenylation and degradation
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp36l2
    Homologene
    FAMILY
  • tristetraprolin family of CCCH tandem zinc finger proteins
  • TIS 11 family of early response genes
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text shuttle between the nucleus and cytoplasm
    basic FUNCTION
  • functioning in regulating the response to growth factors
  • having a functional role of CCCH zinc finger genes in the regulation of macrophage activation (Liang 2008)
  • role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interact with AU-rich elements in the 3prime untranslated region of mRNA, which leads to mRNA degradation and translational repression
  • ZFP36L2, associated previously only with female fertility and hematopoiesis, regulates REST mRNA stability
  • cell & other
    REGULATION
    induced by growth factors and tumor promoters tetradecanoyl phorbol acetate (TPA)
    a broad variety of growth factors and cytokines, and by scratch wounding
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate TP53 target gene that may be part of the network of genes responsible for TP53-dependent apoptosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS