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Symbol ZFP36 contributors: mct/npt/pgu - updated : 18-07-2015
HGNC name zinc finger protein 36, C3H type, homolog (mouse)
HGNC id 12862
Location 19q13.1      Physical location : 39.897.486 - 39.900.045
Synonym name
  • tristetraprolin
  • protein TIS11A
  • growth factor-inducible nuclear protein NUP475
  • G0/G1 switch regulatory protein 24
  • Synonym symbol(s) TIS11, TTP, GOS24, NUP475, EVI24, G0S24, RNF162A, G0S24
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 2.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure
  • a CpG island suggesting expression in the germ line
  • serum response element
  • MAPPING cloned Y linked N status provisional
    Physical map
    FLJ45909 19q13.2 FLJ45909 protein SIRT2 19q13 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) NFKBIB 19q13.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta LOC388539 19 LOC388539 SARS2 19q13.2 seryl-tRNA synthetase 2 MRPS12 19q13.11 mitochondrial ribosomal protein S12 FBXO26 19q13.2 F-box only protein 26 FBXO27 19q13.2 F-box only protein 27 LOC390928 19 similar to RIKEN cDNA C330005M16 LOC284321 19q13.2 hypothetical LOC284321 PAK4 19q13.2 p21(CDKN1A)-activated kinase 4 LOC342897 19q13.2 similar to F-box only protein 2 SYCN 19q13.2 syncollin IL28B 19q13.13 interleukin 28B (interferon, lambda 3) LOC390929 19 similar to Methionine-R-sulfoxide reductase (Selenoprotein X 1) (HSPC270) IL28A 19q13.13 interleukin 28A (interferon, lambda 2) IL29 19q13.13 interleukin 29 (interferon, lambda 1) KIAA1484 GMFG 19p13.2-p12 glia maturation factor, gamma FLJ10211 19q13.2 hypothetical protein FLJ10211 PD2 19q13.1 hypothetical protein F23149_1 Intersex 19q13.2 homolog of Drosophila Intersex ZFP36 19q13.1 zinc finger protein 36, C3H type, homolog (mouse) CLG 19q13.2 likely ortholog of mouse common-site lymphoma/leukemia GEF RPS16 19q13.1 ribosomal protein S16 SUPT5H 19q13 suppressor of Ty 5 homolog (S. cerevisiae) TIMM50 19q13.2 translocase of inner mitochondrial membrane 50 homolog (yeast) DLL3 19q13.1-13.3 delta-like 3 (Drosophila) SELV 19q13.2 selenoprotein V FLJ38944 19q13.2 hypothetical protein FLJ38944 MGC20452 LOC390930 19 similar to Charot-Leyden crystal protein; Charcot-Leyden crystal protein; eosinophil lysophospholipase; lysolecithin acylhydrolase; galactin-10 PP13 19q13.1 placental protein 13 LOC390931 19 similar to placental protein 13-like protein LOC148003 19q13.2 similar to placental protein 13; galectin-13 LOC390932 19 similar to Eosinophil lysophospholipase (Charcot-Leyden crystal protein homolog) (Lysolecithin acylhydrolase) (CLC) (Galectin-10) PPL13 19q13.2 placental protein 13-like protein CLC 19q13.1 Charot-Leyden crystal protein LOC342900 19q13.2 hypothetical LOC342900
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1745 34 326 - 2008 17606294
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousgangliasensory gangliadorsal root  
     nerve   highly
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
    Respiratorylung   highly
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    cell cycle     cell cycle, checkpoint
    Text placenta
  • Kruppel-associated box at the N-terminus
  • two C3H1-type zinc fingers
  • a basic proline-rich domain
  • one KRAB domain
  • potential phosphorylation sites including the sequence PSPTSPT
  • three tetraproline repeats
  • a serine-rich region
  • a serine-phenylalanine "SFS" and an "arginine element " (RRLPIF) at the carboxyl terminus
  • a nuclear localization signal (NLS)
  • a nuclear export signal (NES)
  • conserved C-terminal motif in ZFP36 that directly binds a central domain of CNOT1, a core subunit of the CCR4-NOT complex
  • conjugated MetalloP
    interspecies ortholog to murine tristetraprolin (Zfp-36)
    homolog to C.elegans y48g8ar.c
  • Krüppel family of C2H2-type zinc finger protein
  • TIS11 family of early-response genes
  • zinc finger protein-36 family
  • CATEGORY regulatory , RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    text cytosolic in macrophages
    basic FUNCTION
  • inhibiting macrophage TNF-alpha production by destabilizing its mRNA
  • involved in regulating the response to growth factors
  • physiological regulator of GM-CSF mRNA deadenylation and stability
  • having a functional role of CCCH zinc finger genes in the regulation of macrophage activation
  • destabilizes a number of inflammatory mediators via its zinc finger-mediated interaction with AREs
  • AU-rich elements (ARE)-binding protein that promotes degradation of ARE-containing transcripts
  • involved in regulation of LATS2 transcript stability (may modulate the effect of this protein on cell proliferation)
  • involved in post-transcriptional regulation of BIRC3 expression
  • modulates macrophage inflammatory activity by destabilizing cytokine mRNAs
  • could control IL17-mediated inflammation
  • CCCH tandem zinc finger proteins that can bind to AU-rich elements in mRNAs and promote their decay
  • ZFAND5 and ZFP36 coordinately regulate many ARE-encoding proinflammatory genes at the level of mRNA decay
  • RNA-binding protein that controls the inflammatory response by limiting the expression of several proinflammatory cytokines
  • ZFP36 plays an important role in RIPK1-dependent cell death in conditions where IAPs are depleted
  • regulates the expression of AU-rich element-containing mRNAs through promoting the degradation and repressing the translation of target mRNA
  • promotes translation repression and degradation of mRNAs containing AU-rich elements (AREs)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    metabolism other
    mRNA catabolism
    a component
    RNA binding to AU-rich element in TNF-alpha mRNA
    small molecule metal binding,
  • Zn2+
  • protein
  • downregulates IL6 gene expression at the post-transcriptional level by targeting ARE elements in the 3prime UTR region
  • interaction between ZFP36 and CCL3 mRNA plays an important role in modulating localized inflammatory processes in tissues that are dissociated from the systemic manifestations of chronic inflammation
  • PRR5L associates with ZFP36 to accelerate ZFP36-mediated mRNA turnover and functionally links the control of ZFP36-regulated mRNA stability to MTORC2 activity (
  • general translational repressor DDX6 may cooperate with ZFP36 to regulate AU-rich elements (AREs)-mRNA translation
  • could bind to certain isoforms of another AU-rich element-binding protein, HNRNPD, as well as a related protein, laAUF
  • ZFAND5 competes with ZFP36 for association with AU-rich elements (AREs)-RNA, suppresses ZFP36-induced deadenylation, and interferes with the destabilizing effect of ZFP36 toward ARE-RNA
  • HNRNPF is a co-factor in a subset of ZFP36/BRF1-mediated mRNA decay
  • ZFP36 recruits eukaryotic initiation factor 4E2 (EIF4E2) to repress target mRNA translation
  • ZFP36 promotes the assembly of the death complex called Ripoptosome and induces RIPK1-dependent death
  • cell & other
    induced by early response gene induced by growth factors and tumor promoters (tetradecanoyl phorbol acetate (TPA)
    insulin and growth factor
    Other localized by YWHAx (14-3-3) genes to the cytoplasm
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    expression restricted to the cells in the synovial lining layer in rheumatoid arthritis
    constitutional     --over  
    its overexpression reduced the expression level of LATS2)
  • to rheumatoid arthritis (RA) in African-Americans
  • to Graves ophthalmopathy
  • Variant & Polymorphism SNP , other
  • polymorphisms increasing the risk of rheumatoid arthritis (RA) in African-Americans
  • rs1057745 and rs11083522 in ZFP36 were associated with Graves ophthalmopathy
  • Candidate gene
    Therapy target
    mice deficient in ttp