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FLASH GENE
Symbol ZFAND6 contributors: mct - updated : 09-07-2013
HGNC name zinc finger, AN1-type domain 6
HGNC id 30164
Location 15q25.1      Physical location : 80.352.020 - 80.430.710
Synonym name
  • protein assiociated with PRK1
  • zinc finger, A20 domain containing 3
  • AN1-type zinc finger protein 6
  • Synonym symbol(s) AWP1, ZFAND5B, ZA20D3
    DNA
    TYPE functioning gene
    STRUCTURE 78.83 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1827 - 208 - 2000 11054541
    7 - 1743 - 208 - 2000 11054541
    7 - 1672 - 196 - 2000 11054541
    6 - 1664 - 208 - 2000 11054541
    5 - 1550 - 170 - 2000 11054541
    8 - 1698 - 208 - 2000 11054541
    7 - 1673 - 208 - 2000 11054541
    7 - 1672 - 208 - 2000 11054541
    6 - 1509 - 208 - 2000 11054541
    6 - 1504 - 181 - 2000 11054541
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal A20-like zinc finger domain, responsible for the negative regulation of nuclear factor kappaB activation
  • C terminal AN1 zinc finger domain, mediated the functional interaction with TRAF2
  • HOMOLOGY
    interspecies homolog to murine Zfp216
    Homologene
    FAMILY zinc finger family
    CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • polyubiquitin binding protein involved in NF-kappaB signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to TRAF2 and regulates tumor necrosis factor alpha-induced nuclear factor kappaB activation through two distinct domains (directly interacted with the C-terminal tumor necrosis factor receptor-associated factor (TRAF) domain of TRAF2)
  • ubiquitin-binding NFKB1 modulator
  • interacted with PEX6 AAA ATPase, but not with PEX1-PEX6 complexes
  • novel cofactor of PEX6 involved in the regulation of PEX5 export during peroxisome biogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    inhibited nuclear factor kappaB activation
    constitutional     --over  
    repressed NF-kappaB activity in a manner similar to optineurin, while siRNAs directed against ZFAND6 and RIOK3 also reduced NF-kappaB activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS