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FLASH GENE
Symbol ZER1 contributors: mct - updated : 11-06-2020
HGNC name zer-1 homolog (C. elegans)
HGNC id 30960
Location 9q34.11      Physical location : 131.492.066 - 131.534.198
Synonym name
  • ZYG homolog
  • chromosome 9 open reading frame 60
  • zyg-11 homolog B (C. elegans)-like
  • Synonym symbol(s) ZYG, C9orf60, RP11-545E17.4, ZYG11BL
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    STRUCTURE 42.70 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4293 88 766 - 2001 11719588
    16 splicing 4059 - 766 only in testis 2001 11719588
    16 - 4081 - 766 - 2001 11719588
    16 - 4716 - 766 - 2001 11719588
    16 - 4287 - 764 - 2001 11719588
    16 - 4053 - 764 - 2001 11719588
    15 - 3870 - 703 - 2001 11719588
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunelymph node    
     thymus    
    Reproductivefemale systemovary   
     female systembreastmammary gland  
     male systemprostate   
     male systemtestis   
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five ARM repeats domains
  • HOMOLOGY
    interspecies ortholog to murine Zyg11bl
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may have an important role during meiosis
  • ZER1 is required for the binding of HPV16 E7 to CUL2
  • ZYG11B and ZER1 were found to participate in the quality control of N-myristoylated proteins, in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation
  • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS