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FLASH GENE

Symbol

ZDHHC9

contributors: mct - updated : 03-10-2018

HGNC name	zinc finger, DHHC-type containing 9
HGNC id	18475

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	LJFS2 Lujan-Fryns syndrome 2
Location	Xq26.1      Physical location : 128.937.263 - 128.977.910
Synonym name	Asp-His-His-Cys domain containing protein 9
	zinc finger, DHHC-type containing 10
	zinc finger, DHHC domain containing 9
	chromosome X open reading frame 11
	palmitoyltransferase ZDHHC9
Synonym symbol(s)	CGI-89, ZNF379, DHHC9, CXorf11, ZDHHC10, ZNF379, ZNF380, LOC51114, UNQ261/PRO298, CGI89, MMSA1, MRXSR
EC.number	2.3.1.225

DNA

TYPE	functioning gene
STRUCTURE	40.65 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016032 11 - 4619 NP_057116 44 364 - 2005 16000296 NM_001008222 10 - 4639 NP_001008223 44 364 - 2005 16000296

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         mouth       highly Nervous brain       highly Reproductive male system prostate     highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved Cys four zinc-finger like metal binding domain
	a complex Cys-His region
	a DHHC/NEW1 cysteine-rich domain potentially involved in protein-protein or protein-DNA interaction, zinc-finger (aspartic acid-histidine-histidine-cysteine) domain in the cytoplasmic loop
	four predicted transmembrane spans
	a proline-rich domain

HOMOLOGY

interspecies	homolog to Drosophila DNZ1
	ortholog to the yeast Ras palmitoyltransferase

Homologene

FAMILY	zinc finger protein family
	DHHC palmitoyltransferase family
	DHHC/NEW1 subfamily

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	integral membrane protein

basic FUNCTION	palmitoyltransferase catalyzing the posttranslational modification of NRAS and HRAS
	may have a functional palmitoyltransferase activity associated with GOLGA7

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

of a complex formed by ERF4, GOLGA7 and ZDHHC9

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	requires GOLGA7 for protein fatty acyltransferase activity and protein stability
	during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action of the S-acyltransferases ZDHHC20 and ZDHHC9

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LJFS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   promotes, while repressing it diminishes, RAS Plasma Membrane localization and transformation of mammalian cells constitutional     --over   promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS