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FLASH GENE
Symbol ZDHHC6 contributors: npt - updated : 09-01-2013
HGNC name zinc finger, DHHC domain containing 6
HGNC id 19160
Location 10q25.2      Physical location : 114.190.059 - 114.206.672
Synonym name
  • probable palmitoyltransferase ZDHHC6
  • transmembrane protein H4
  • zinc finger protein 376
  • Synonym symbol(s) ZNF376, FLJ21952
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 16.62 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    XPNPEP1 10q25.3 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble RNU4P5 10q25.2 RNA, U4 small nuclear pseudogene 5 ADD3 10q24.2-q24.3 adducin 3 (gamma) MXI1 10q25 MAX interacting protein 1 SMNDC1 10q23 survival motor neuron domain containing 1 DUSP5 10q25 dual specificity phosphatase 5 CSPG6 10q25 chondroitin sulfate proteoglycan 6 (bamacan) LOC340699 10q25.3 similar to 1110018J23Rik protein PDCD4 10q24 programmed cell death 4 (neoplastic transformation inhibitor) SHOC2 10q25 soc-2 suppressor of clear homolog (C. elegans) ADRA2A 10q25 adrenergic, alpha-2A-, receptor KIAA1560 10q25.3 glycerol 3-phosphate acyltransferase, mitochondrial TECTB 10q25-q26 tectorin beta LOC390003 10 similar to guanylyl cyclase with kinase-like domain, soluble FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1 AMACO 10q26.11 A-domain containing protein similar to matrilin and collagen STK6LP 10q25-q26 serine/threonine kinase 6-like pseudogene LOC390005 10 similar to AMACO FLJ14564 10q26.11 hypothetical protein FLJ14564 ABLIM1 10q25 actin binding LIM protein 1 LOC390006 10 similar to peptidylprolyl isomerase A (cyclophilin A) KIAA1600 10q26.11 KIAA1600 protein TRUB1 10q26.11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) KIAA0534 10q26 KIAA0534 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2187 - 413 - 1999 10395086
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region
  • DHHC/NEW1 domain, potentially involved in protein-protein or protein-DNA interaction
  • ER targeting signal in DHHC6 is conform to a KKXX motif, C-terminal pentapeptide sequences required for ER localization of DHHC4 and DHHC6
  • HOMOLOGY
    interspecies homolog to Drosophila DNZ1
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • DHHC/NEW1 subfamily
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • restricted localization of ZDHHC4 and ZDHHC6 to ER membranes
  • basic FUNCTION
  • putative transcription factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS