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FLASH GENE
Symbol ZDHHC5 contributors: mct - updated : 25-05-2010
HGNC name zinc finger, DHHC domain containing 5
HGNC id 18472
Location 11q12.1      Physical location : 57.435.473 - 57.468.659
Synonym name
  • probable palmitoyltransferase ZDHHC5
  • membrane-associated DHHC5 zinc finger protein
  • Synonym symbol(s) ZNF375, KIAA1748, DKFZp586K0524
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 33.18 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4582 - 715 - Li (2010)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region, DHHC/NEW1 domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Zdhhc5 (98.0)
    homolog to Drosophila DNZ1
    homolog to murine Zdhhc5 (97.9pc)
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • ERF2/ZDHHC9 subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • ZDHHC5 and SSTR5 are colocalized at the plasma membrane
  • basic FUNCTION putative transcription factor
    CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+ binding
  • protein
  • SSTR5 interacting with the N-terminal region of the putative palmitoyltransferase ZDHHC5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice homozygous for a hypomorphic allele of Zdhhc5 are born with a marked deficit in contextual fear conditioning (Li 2010)