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FLASH GENE
Symbol ZDHHC3 contributors: mct/npt/pgu - updated : 09-01-2018
HGNC name zinc finger, DHHC-type containing 3
HGNC id 18470
Location 3p21.31      Physical location : 44.956.753 - 45.017.674
Synonym name
  • palmitoyltransferase ZDHHC3
  • DHHC1 protein
  • Golgi apparatus-specific protein with DHHC zinc finger
  • domain
  • zinc finger protein 373
  • Synonym symbol(s) GODZ, ZNF373, FLJ20209, FLJ45940, DKFZp313D2314, DHHC-3
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 50.95 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 12714 - 327 - 2002 12163046
    7 - 3926 - 329 - 2002 12163046
    7 - 12630 - 299 - 2002 12163046
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region
  • DHHC/NEW1 domain
  • potentially involved in protein-protein or protein-DNA interaction
  • four transmembrane segments
  • HOMOLOGY
    interspecies homolog to Drosophila DNZ1
    Homologene
    FAMILY
  • DHHC/GODZ subfamily
  • DHHC palmitoyltransferase family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • with ZDHHC17, co-localized to the Golgi and the same post-Golgi vesicles, suggesting that heteropalmitoylation might play a physiological role in addition to a biochemical function
  • basic FUNCTION
  • putative transcription factor playing a role in the membrane protein trafficking
  • DHHC family palmitoyl acyltransferase that is implicated in palmitoylation and regulated trafficking of diverse substrates that function either at inhibitory or excitatory synapses
  • mediating palmitoylation of GABA(A) receptors and possibly other substrates contributes selectively to the formation and normal function of GABAergic inhibitory synapses
  • with ZDHHC2, are differentially regulated and dynamic recruitment of protein palmitoylation machinery enables compartmentalized regulation of protein trafficking in response to extracellular signals
  • mediates the palmitoylation and post-translational modification of many protein substrates that regulate membrane-protein interactions
  • encodes a Ca(2+) transport protein in addition to its ability to palmitoylate protein substrates
  • co-expression of DHHC acyltransferases (DHHC3 or DHHC7), but not their acyltransferase-inactive mutants, increased expression levels of RGS4
  • may potentially undergo some post-translational modification following its exit from the ER
  • DHHC3 localized to ER membranes is an active palmitoyltransferase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • involved in the palmitoylation of SNAP25
  • palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6/beta4
  • ZDHHC3 and ZDHHC8, also interacted with the DRD2 and each of the palmitoyl acyltransferase (PAT) was capable of affecting the palmitoylation status of the DRD2
  • ZDHHC3 promotes breast tumor growth, by a mechanism involving palmitoylation of key substrate proteins such as ERGIC3
  • Cys141 and Cys498 AAs on ACE2 are S-palmitoylated by ZDHHC3 and de-palmitoylated by LYPLA1, which is critical for the membrane-targeting of ACE2 and their extracellular vesicles (EVs) secretion to interacts with the viral spike (S) protein of the SARS-CoV-2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS