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FLASH GENE
Symbol ZDHHC3 contributors: mct/npt/pgu - updated : 09-01-2013
HGNC name zinc finger, DHHC-type containing 3
HGNC id 18470
Location 3p21.31      Physical location : 44.956.753 - 45.017.674
Synonym name
  • palmitoyltransferase ZDHHC3
  • DHHC1 protein
  • Golgi apparatus-specific protein with DHHC zinc finger
  • domain
  • zinc finger protein 373
  • Synonym symbol(s) GODZ, ZNF373, FLJ20209, FLJ45940, DKFZp313D2314, DHHC-3
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 50.95 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ36157 3p21.32 FLJ36157 protein DKFZp313N0621 3p21.32 hypothetical protein DKFZp313N0621 LOC285344 3p21.32 similar to hypothetical protein MG11009.4 ZNF445 3p21.32 zinc finger protein 445 LOC285346 3p21.32 hypothetical protein LOC285346 ZNF167 3p22-p21 zinc finger protein 167 LOC389115 3 hypothetical gene supported by BC009982; NM_015134 FLJ36870 3p21.32 hypothetical protein FLJ36870 ZNF197 3p21.2-p21.1 zinc finger protein 197 ZNF35 3p21 zinc finger protein 35 (clone HF.10) LOC391531 3 similar to zinc finger protein 347; zinc finger 1111 LOC389116 3 hypothetical gene supported by AL136896; NM_014011 ZNF502 3p21.32 zinc finger protein 502 ZNF501 3p21.32 zinc finger protein 501 KIAA1143 3p21.32 KIAA1143 protein KNSL7 3p21.33 kinesin-like 7 MGC29956 3p21.32 hypothetical protein MGC29956 LOC391532 3 similar to peptidyl-Pro cis trans isomerase TGM4 3p22-p21.3 transglutaminase 4 (prostate) FLJ20209 3p21.32 hypothetical protein FLJ20209 ZDHHC3 3p21.32 zinc finger, DHHC domain containing 3 KIAA0116 3p21 Homo sapiens KIAA0116 protein (KIAA0116), mRNA. TNA 3p21.3 tetranectin (plasminogen binding protein) CDCP1 3p24.3-p22.1 tetranectin (plasminogen binding protein) RIS1 3p21.3 tetranectin (plasminogen binding protein) LARS2 3p21.3 leucyl-tRNA synthetase 2, mitochondrial LIMD1 3p21.3 LIM domains containing 1 SACM1L 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) XT3 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) LZTFL1 3p21.3 leucine zipper transcription factor-like 1 CCR9 3p21.3 chemokine (C-C motif) receptor 9
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 12714 - 327 - 2002 12163046
    7 - 3926 - 329 - 2002 12163046
    7 - 12630 - 299 - 2002 12163046
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region
  • DHHC/NEW1 domain
  • potentially involved in protein-protein or protein-DNA interaction
  • four transmembrane segments
  • HOMOLOGY
    interspecies homolog to Drosophila DNZ1
    Homologene
    FAMILY
  • DHHC/GODZ subfamily
  • DHHC palmitoyltransferase family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • with ZDHHC17, co-localized to the Golgi and the same post-Golgi vesicles, suggesting that heteropalmitoylation might play a physiological role in addition to a biochemical function
  • basic FUNCTION
  • putative transcription factor playing a role in the membrane protein trafficking
  • DHHC family palmitoyl acyltransferase that is implicated in palmitoylation and regulated trafficking of diverse substrates that function either at inhibitory or excitatory synapses
  • mediating palmitoylation of GABA(A) receptors and possibly other substrates contributes selectively to the formation and normal function of GABAergic inhibitory synapses
  • with ZDHHC2, are differentially regulated and dynamic recruitment of protein palmitoylation machinery enables compartmentalized regulation of protein trafficking in response to extracellular signals
  • mediates the palmitoylation and post-translational modification of many protein substrates that regulate membrane-protein interactions
  • encodes a Ca(2+) transport protein in addition to its ability to palmitoylate protein substrates
  • co-expression of DHHC acyltransferases (DHHC3 or DHHC7), but not their acyltransferase-inactive mutants, increased expression levels of RGS4
  • may potentially undergo some post-translational modification following its exit from the ER
  • DHHC3 localized to ER membranes is an active palmitoyltransferase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • involved in the palmitoylation of SNAP25
  • palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6/beta4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS