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FLASH GENE
Symbol ZDHHC20 contributors: mct - updated : 28-12-2021
HGNC name zinc finger, DHHC domain containing 20
HGNC id 20749
Location 13q12.11      Physical location : 21.950.509 - 22.033.423
Synonym name
  • DHHC-containing protein 20
  • zinc finger, DHHC domain containing 20
  • Synonym symbol(s) FLJ25952, DHHC20, DHHC-20, 4933421L13Rik, MGC126005
    EC.number 2.3.1.225
    DNA
    TYPE functioning gene
    STRUCTURE 86.78 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 5250 - 292 - 2020 31858978
    12 - 5274 - 354 - 2020 31858978
    13 - 5355 - 365 - 2020 31858978
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nuclear envelope
    basic FUNCTION
  • ZDHHC17, ZDHHC18, ZDHHC20, and ZDHHC21 exhibited weak or moderate activities
  • DHHC20 induces a drastic deformation in the membrane, particularly on the cytoplasmic side, where autoacylation occurs
  • palmitoyltransferase DHHC20 palmitoylates EGFR on the C-terminal domain and plays a critical role in signal regulation during oncogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZDHHC20 uniquely increased IFITM3 antiviral activity when both proteins were overexpressed
  • during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action of the S-acyltransferases ZDHHC20 and ZDHHC9
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS