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FLASH GENE
Symbol ZDHHC2 contributors: mct/shn - updated : 29-02-2012
HGNC name zinc finger, DHHC domain containing 2
HGNC id 18469
Location 8p22      Physical location : 17.013.835 - 17.080.240
Synonym name
  • palmitoyltransferase ZDHHC2
  • ream
  • rec
  • reduced expression associated with metastasis protein
  • reduced expression in cancer protein
  • zinc finger DHHC domain-containing protein 2
  • zinc finger protein 372
  • zinc finger, DHHC domain containing 2
  • Synonym symbol(s) ZNF372, REAM, DHHC2, DHHC-2
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 66.41 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D8S549 - D8S254 - ZDHHC2 - D8S261 - D8S1715 - qter
    Physical map
    N33 8p22 hypothetical protein FLJ10569 LOC137012 8p22 protein phosphatase 1A pseudogene LOC392202 8 similar to 60S ribosomal protein L32 MSR1 8p22 macrophage scavenger receptor 1 LOC392203 8 similar to matricin MRPL49P2 8p22 similar to matricin FGF20 8p22-p21.3 fibroblast growth factor 20 LOC286097 8p22 hypothetical protein LOC286097 ZDHHC2 8p21.3-p22 zinc finger, DHHC domain containing 2 CNOT7 8p22-p21.3 CCR4-NOT transcription complex, subunit 7 FLJ32642 8p22 hepatocellular carcinoma related protein 1 MTMR7 8p22 myotubularin related protein 7 LOC392204 8 similar to ADAM 25 precursor (A disintegrin and metalloproteinase domain 25) (Testase 2) SLC7A2 8p22-p21.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 PDGFRL 8p22-p21.3 platelet-derived growth factor receptor-like MTSG1 8p22 mitochondrial tumor suppressor gene 1 LOC389636 8 LOC389636 FGL1 8p22-p21.3 fibrinogen-like 1 PCM1 8p22-p21.3 pericentriolar material 1 ASAH1 8p22-p21.3 N-acylsphingosine amidohydrolase (acid ceramidase) 1 MRPS18CP3 8p21.3 mitochondrial ribosomal protein S18C pseudogene 3 UNQ9391 8p23.1 tryptophan/serine protease NAT1 8p22 N-acetyltransferase 1 (arylamine N-acetyltransferase) LOC392205 8 similar to acetyltransferase LOC392206 8 similar to ribosomal protein L10a NAT2 8p22 N-acetyltransferase 2 (arylamine N-acetyltransferase) DKFZp761K1423 8p22 hypothetical protein DKFZp761K1423 EFA6R 8pter-p23.3 hypothetical protein DKFZp761K1423 LOC389637 8 LOC389637 LOC389638 8 LOC389638 LOC392207 8 similar to PMCA2av FLJ20967 8p21.2 hypothetical protein FLJ20967 ChGn 8p21.3 chondroitin beta1,4 N-acetylgalactosaminyltransferase FLJ10569 8p21.3 hypothetical protein FLJ10569 LPL 8p22 lipoprotein lipase
    regionally located located in a region commonly deleted in colorectal and hepatocellular carcinomas
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 4012 - 367 - 2008 18508921
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver   moderately
     pancreas exocrine    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region
  • an Asp-His-His-Cys (DHHC) motif
  • DHHC/NEW1 domain, potentially involved in protein-protein or protein-DNA interaction
  • four transmembrane segments
  • cytoplasmic C-terminus regulates membrane targeting
  • HOMOLOGY
    interspecies homolog to Drosophila Dnz1
    ortholog to Zdhhc2, Mus musculus
    ortholog to Zdhhc2, Rattus norvegicus
    ortholog to zdhhc2, Danio rerio
    ortholog to ZDHHC2, Pan troglodytes
    Homologene
    FAMILY
  • DHHC palmitoyltransferase
  • CATEGORY enzyme , DNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • dendritic vesicles of unknown origin in neurons (
  • basic FUNCTION
  • palmitoyl acyltransferase
  • stimulates palmitoylation of tetraspanins CD9 and CD151
  • ZDHHC2-dependent palmitoylation had multiple functional effects, promoting physical associations between CD9 and CD151, and between alpha3 integrin and other proteins
  • important role for DHHC2-mediated palmitoylation of CKAP4 in opposing cancer-related cellular behaviors, supporting the idea that DHHC2 is a tumor suppressor
  • with ZDHHC3, are differentially regulated and dynamic recruitment of protein palmitoylation machinery enables compartmentalized regulation of protein trafficking in response to extracellular signals
  • candidate enzyme to regulate SNAP25/23 palmitoylation dynamics at the plasma membrane
  • mediates de novo and turnover palmitoylation of R7BP (
  • localizes to dendritic vesicles of unknown origin in neurons, where it regulates dynamic palmitoylation of DLG4
  • capable of palmitoylating of Lck in T cells (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • CKAP4/p63 (
  • CD9 and CD151(
  • cytoskeleton-associated protein 4, CKAP4
  • cell & other
  • the plasma membrane, RAB11-positive recycling endosomes, and vesicular structures
  • REGULATION
    inhibited by 2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation deletion    
    in colorectal carcinomas, hepatocellular carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Reducing the DHHC2 level in Jurkat T cells using siRNA causes decreased Lck S-acylation and partial dislocation from membranes, and conversely overexpression of DHHC2 increases S-acylation of an Lck surrogate, LckN10-GFP (