Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZDHHC16 contributors: mct/npt - updated : 13/12/2008
HGNC name zinc finger, DHHC domain containing 16
HGNC id 20714
Location 10q24.1      Physical location : 99.205.929 - 99.217.124
Synonym name
  • Abl-philin 2
  • region containing Transcription factor IIFalpha; hypothetical protein
  • MGC2993
    Synonym symbol(s) RP11-452K12.10, APH2, MGC2993, DHHC-16
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 11.19 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TMEM10 10q23-q24 transmembrane protein 10 TLL2 10q23-q24 tolloid-like 2 SMBP 10q24.2 SM-11044 binding protein PIK3AP1 10q24.2 phosphoinositide-3-kinase adaptor protein 1 LOC283340 10q24.2 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC387709 10 LOC387709 C10orf12 10q24.2 chromosome 10 open reading frame 12 SLIT1 10q23.3-q24 slit homolog 1 (Drosophila) ARHGAP19 10q24.2 Rho GTPase activating protein 19 FRAT1 10q24.1 frequently rearranged in advanced T-cell lymphomas FRAT2 10q23-q24.1 frequently rearranged in advanced T-cell lymphomas 2 KIAA0690 10q23.33 frequently rearranged in advanced T-cell lymphomas 2 PGAM1 10q25.3 phosphoglycerate mutase 1 (brain) CSL4 10q24 exosomal core protein CSL4 ZDHHC16 10q24.1 zinc finger, DHHC domain containing 16 MMS19L 10q24-q25 MMS19-like (MET18 homolog, S. cerevisiae) FLJ11807 10q24.2 hypothetical protein FLJ11807 ANKRD2 10q23.31-q23.32 ankyrin repeat domain 2 (stretch responsive muscle) LOC112817 10q24.2 hypothetical protein BC011916 LOC118812 10q24.2 44050 protein PI4KII 10q24 44050 protein VIP32 10q24.2 vasopressin-induced transcript MGC4415 10q24.2 hypothetical protein MGC4415 FLJ32919 10q24.2 hypothetical protein FLJ32919 SFRP5 10q24.1 secreted frizzled-related protein 5 CRTAC1 10q22 cartilage acidic protein 1 C10orf28 10q24.2 chromosome 10 open reading frame 28 LOXL4 10q24 lysyl oxidase-like 4 C10orf33 10q24.2 chromosome 10 open reading frame 33 HPS1 10q23.1-q23.3 Hermansky-Pudlak syndrome 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1816 43 377 ovary, placenta Li, Zhang (2006)
    11 - 1768 - 361 - Li, Zhang (2006)
    10 - 1699 - 338 - Li, Zhang (2006)
    9 - 1581 - 296 - Li, Zhang (2006)
    12 - 1973 43 377 - Li, Zhang (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DHHC-type zinc finger
  • HOMOLOGY
    interspecies homolog to murine Zdhhc16
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • predominant distribution in the cytoplasm and co-localized with COPS5 around the nucleus
  • with ABL1 are co-localized in the ER region
  • basic FUNCTION
  • having a pro-apoptotic activity
  • involved in AP-1 regulation by interaction with COPS5
  • may be involved in ER stress-induced apoptosis in which ABL2 plays an important role
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with c-Ab1
  • interaction with COPS5 (the zf-DHHC domain and the C-terminal of COPS5 were confirmed to be critical for the interaction)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS