SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,nucleus
|
text
| predominant distribution in the cytoplasm and co-localized with COPS5 around the nucleus |
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with ABL1 are co-localized in the ER region |
basic FUNCTION
| having a pro-apoptotic activity |
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involved in AP-1 regulation by interaction with COPS5 |
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may be involved in ER stress-induced apoptosis in which ABL2 plays an important role |
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ZDHHC16 exhibited the highest activity, followed by ZDHHC7 and ZDHHC15 |
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is a critical regulator of cardiac function, revealing roles for protein palmitoylation in the development of other organs including eyes |
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ZDHHC16 activity is likely essential for early neural stem/progenitor cells (NSPCs) proliferation where it acts to activate the FGF/ERK network, allowing for the initiation of proliferation -regulated gene expression programs |
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potential role for protein palmitoylation and ZDHHC16 in DNA damage response |