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FLASH GENE
Symbol ZDHHC16 contributors: mct/npt - updated : 28-12-2021
HGNC name zinc finger, DHHC domain containing 16
HGNC id 20714
Location 10q24.1      Physical location : 99.205.929 - 99.217.124
Synonym name
  • Abl-philin 2
  • region containing Transcription factor IIFalpha; hypothetical protein
  • MGC2993
    Synonym symbol(s) RP11-452K12.10, APH2, MGC2993, DHHC-16
    EC.number 2.3.1.-/ 2.3.1.225
    DNA
    TYPE functioning gene
    STRUCTURE 11.23 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1797 43 377 ovary, placenta 2015 26644582
    10 - 1749 - 361 - 2015 26644582
    10 - 1680 - 338 - 2015 26644582
    9 - 1581 - 296 - 2015 26644582
    12 - 1977 43 377 - 2015 26644582
    12 - 1923 - 359 - 2015 26644582
    8 - 1587 - 307 - 2015 26644582
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DHHC-type zinc finger
  • HOMOLOGY
    interspecies homolog to murine Zdhhc16
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • predominant distribution in the cytoplasm and co-localized with COPS5 around the nucleus
  • with ABL1 are co-localized in the ER region
  • basic FUNCTION
  • having a pro-apoptotic activity
  • involved in AP-1 regulation by interaction with COPS5
  • may be involved in ER stress-induced apoptosis in which ABL2 plays an important role
  • ZDHHC16 exhibited the highest activity, followed by ZDHHC7 and ZDHHC15
  • is a critical regulator of cardiac function, revealing roles for protein palmitoylation in the development of other organs including eyes
  • ZDHHC16 activity is likely essential for early neural stem/progenitor cells (NSPCs) proliferation where it acts to activate the FGF/ERK network, allowing for the initiation of proliferation -regulated gene expression programs
  • potential role for protein palmitoylation and ZDHHC16 in DNA damage response
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with c-Ab1
  • interaction with COPS5 (the zf-DHHC domain and the C-terminal of COPS5 were confirmed to be critical for the interaction)
  • ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Aph2(-/-) embryos and pups showed cardiomyopathy and cardiac defects including bradycardia