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FLASH GENE

Symbol

ZDHHC11

contributors: mct/npt - updated : 13-02-2016

HGNC name	zinc finger, DHHC domain containing 11
HGNC id	19158

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5p15.33      Physical location : 795.719 - 851.101
Synonym name	zinc finger protein 399
Synonym symbol(s)	ZNF399, FLJ13153, DHHC-11
EC.number	2.3.1.-

DNA

TYPE	functioning gene
STRUCTURE	55.38 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024786 13 - 2618 NP_079062 - 412 - Isogai, Yamamoto (2007)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas islet of Langerhans       Reproductive male system testis       Respiratory lung         Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

widely

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved Cys 4 zinc-finger like metal binding domain
	a complex Cys-His region, DHHC/NEW1 domain, potentially involved in protein-protein or protein-DNA interaction

HOMOLOGY

interspecies

homolog to Drosophila DNZ1

Homologene

FAMILY

DHHC palmitoyltransferase family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

putative transcription factor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+ binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in early stages of non-small cell lung cancer (Kang 2008) tumoral   amplification     in high-grade bladder cancers (Yamamoto 2007) constitutional     --over   promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry

Susceptibility

Variant & Polymorphism

Candidate gene	potential biomarker identifying high-risk patients with disease progression in bladder cancer (Yamamoto 2007)
Marker
Therapy target

ANIMAL & CELL MODELS