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FLASH GENE
Symbol ZCCHC8 contributors: mct - updated : 21-08-2013
HGNC name zinc finger, CCHC domain containing 8
HGNC id 25265
Location 12q24.31      Physical location : 122.957.435 - 122.985.518
Genatlas name Zn-knuckle protein
Synonym symbol(s) DKFZp434E2220
DNA
TYPE functioning gene
STRUCTURE 29.40 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4183 - 707 - 2005 16263084
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrinethyroid   highly
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunelymph node    
Reproductivemale systemtestis  highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
CCHC-type zinc finger
HOMOLOGY
interspecies ortholog to murine Zcchc8
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
text
  • ZCCHC8 and RBM7 are excluded from nucleoli
  • basic FUNCTION
  • GSK3 substrate with a role in RNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of the trimeric Nuclear Exosome Targeting (NEXT) complex, containing SKIV2L2, the Zn-knuckle protein ZCCHC8, and the putative RNA binding protein RBM7
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein interacts with proteins involved in RNA processing/degradation (directly phosphorylated by GSK3)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS