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FLASH GENE
Symbol ZC3HC1 contributors: - updated : 01-09-2005
HGNC name zinc finger, C3HC type 1
HGNC id 29913
Location 7q32.2      Physical location : 129.658.126 - 129.691.233
Synonym name
  • nuclear interacting partner of anaplastic lymphoma kinase (ALK)
  • hematopoietic stem/progenitor cell protein 216
  • Synonym symbol(s) NIPA, HSPC216
    DNA
    TYPE functioning gene
    STRUCTURE 33.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuteruscervix moderately
    Skin/Tegumentskin   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Nipa
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an anti-apoptotic role in NPM-ALK mediated signaling events
  • being a F-box-containing protein acting as an SCF-type E3 ligase controlling mitotic entry
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SCF-NIPA complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • anaplastic lymphoma kinase (ALK) in a tyrosine kinase-dependent manner
  • cell & other
    REGULATION
    Other phosphorylated on tyrosine and serine residues in NPM-ALK expressing cells
    assembly of SCF-NIPA complex regulated by cell-cycle-dependent phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS