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FLASH GENE
Symbol ZC3H7B contributors: mct - updated : 21-12-2021
HGNC name zinc finger CCCH-type containing 7B
HGNC id 30869
Location 22q13.2      Physical location : 41.697.566 - 41.756.150
Synonym name
  • rotavirus 'X' associated non-structural protein
  • zinc finger type C2H2
  • rotavirus X protein associated with NSP3
  • ubiquitous tetratricopeptide containing protein RoXaN
    • Synonym symbol(s) KIAA1031, FLJ13787, RoXaN, DKFZp434K0920, ROXAN1
    DNA
    TYPE functioning gene
    STRUCTURE 58.58 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5868 - 977 - 2008 18799579
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  predominantly
     stomach   moderately
    Lymphoid/Immunelymph node   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland moderately
    Skin/Tegumentskin   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C2H2-type zinc finger
  • at least five C3H1-type zinc fingers
  • three TPR repeats
  • a paxillin leucine-aspartate repeat (LD) motif
    • HOMOLOGY
    interspecies homolog to murine Zc3h7b (96.4pc)
    homolog to rattus Zc3h7b (96.1pc)
    Homologene
    FAMILY
  • zinc finger family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cellular partner of NSP3 involved in the nucleocytoplasmic localization of PABP-C1 (Harb 2008)
    • CELLULAR PROCESS nucleotide, transcription
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with rotavirus non-structural protein NSP3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ZC3H7B-BCOR gene fusion has been described in a subset of myxoid high-grade endometrial stromal sarcomas
    tumoral fusion      
    ZC3H7B-BCOR fusion in myxoid smooth muscle neoplasia of the uterus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS