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FLASH GENE
Symbol ZC3H3 contributors: - updated : 22-06-2004
HGNC name zinc finger CCCH type domain containing 3
HGNC id 28972
Location 8q24.3      Physical location : 144.519.824 - 144.623.620
Synonym symbol(s) KIAA0150, ZC3HDC3, SMICL
DNA
TYPE functioning gene
STRUCTURE 103.00 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix highly
 female systemovary   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a domain with five CCCH-type zinc fingers
HOMOLOGY
interspecies homolog to murine Zc3hdc3
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • displaying CPSF4-like activities, interacting in the nucleus with activated Smads, and potentiating in TGF-beta stimulated cells SMAD-dependent transcriptional responses, possibly in conjunction with the activity of CPSF complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to SMAD proteins (cooperate and enhance TGF-beta mediated activation of a Smad-responsive reporter gene)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS