expressed in the nucleus of neurons, to nuclear speckle
contain sequences controlling both nuclear localization and nuclear export, suggesting that it may shuttle between nucleus and cytoplasm as part of itsr normal function
basic FUNCTION
may contribute to control of gene expression in human cells through binding poly(A) RNA
could play critical roles in neurons such as ensuring that transcripts are properly targeted to sites of localized translation
zinc finger-containing class of nuclear polyadenosine RNA-binding proteins playing an evolutionarily conserved role in controlling the length of the poly(A) tail in neurons
ZC3H14 has a conserved role in supporting neuronal axon projection and branching
role for ZC3H14 in ensuring proper nuclear processing and retention of ATP5G1 pre-mRNA
ZC3H14 modulates likely pre-mRNA processing of select mRNA transcripts and plays a critical role in regulating cellular energy levels, observations that have broad implications for proper neuronal function
poly(A) RNA binding protein required for intellectual function
ZC3H14 is also a cytoplasmic regulator of neuronal mRNAs
is important in RNA processing
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
binding
RNA
small molecule
protein
binds to HOOK2, a protein previously implicated in aggresome formation
physical interactions between ZC3H14 and multiple RNA processing factors
ATP5G1 and DLG4 are shared RNA targets of ZC3H14 and the THO complex
functions of ZC3H14 linked to the THO complex in the processing of RNA
