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FLASH GENE
Symbol ZC3H12D contributors: mct/npt - updated : 15-04-2008
HGNC name zinc finger CCCH-type containing 12D
HGNC id 21175
Location 6q25.1      Physical location : 149.768.766 - 149.806.148
Synonym name
  • chromosome 6 open reading frame 95
  • MCP induced protein 4
  • Synonym symbol(s) dJ281H8.1, C6orf95, FLJ00361, FLJ46041, MCPIP4, p34
    DNA
    TYPE functioning gene
    STRUCTURE 35.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2384 - 321 - Liang (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Lymphoid/Immunelymph node    
     spleen   highly
     thymus   highly
     tonsils    
    Respiratorylung   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ZF-CCCH domain
  • HOMOLOGY
    Homologene
    FAMILY
  • CCCH-zinc finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • negative regulator in macrophage activation and implicated in host immunity and inflammatory diseases
  • having a functional role of CCCH zinc finger genes in the regulation of macrophage activation (Liang 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by dramatically induced by lipopolysaccharide (LPS) in macrophages
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS