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FLASH GENE
Symbol ZBTB7B contributors: mct - updated : 01-03-2016
HGNC name zinc finger and BTB domain containing 7B
HGNC id 18668
Location 1q213      Physical location : 154.975.111 - 154.990.998
Synonym name
  • zinc finger protein 67 homolog (mouse)
  • zinc finger and BTB domain containing 15
  • T-helper-inducing POZ/Krueppel-like factor
  • kruppel-related zinc finger protein hcKrox
  • Synonym symbol(s) hcKrox, ZFP67, ZBTB15, DKFZp686G01254, c-KROX, ZNF857B, Th-POK
    DNA
    TYPE functioning gene
    STRUCTURE 15.90 kb     5 Exon(s)
    regulatory sequence Binding site   transcription factor
    text structure
  • positive regulatory element in the region 22 bps in length located 600 bp upstream from the transcription initiation site, with a consensus binding sequence for ELK4 and is activated by the Erk pathway
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3630 58 539 - 2007 17878336
    5 - 4030 - 573 - 2007 17878336
    3 - 3790 - 539 - 2007 17878336
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text ectoderm
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BTB-POZ domain
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • Lrox subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptionnal repressor for COL1A1 gene and potentially to fibronectin
  • key function of ZBTB7B in the mature CD4+ T cell compartment is to repress CD8-lineage gene expression
  • its expression in the development and/or acquisition of effector functions by T cells and other is dependent on T-cell receptor signaling and differences in relative TCR signal strength/length may induce different levels of ZBTB7B expression
  • ZBTB7A, ZBTB7B pair are a core node of Th cell differentiation and function
  • is a critical factor genetically predetermining the balance of effector subsets within the NKT cell population
  • may be considered a central regulator of the earliest events in the immune system during colorectal cancer development, decreasing the immune response against cancer cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text ectodermal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to collagen gene promoter
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • cross-regulation between RUNX3 and ZBTB7B contributes to appropriate thymocyte lineage commitment
  • promoter of SERPINA3 is transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B)
  • KAT5 is a co-repressor of ZBTB7B-target genes, where ectopically expressed KAT5 increased ZBTB7B protein stability by promoting its acetylation at its Lys(360) residue
  • ZBTB7A, ZBTB7B unlike in conventional T cells, functions in Tregs are not mediated by their repression of the transcription factor RUNX3
  • orchestrates stochastic interchromosomal interactions required for IFNB1 virus-inducible gene expression
  • cell & other
    REGULATION
    induced by retinoic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS