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FLASH GENE
Symbol ZBTB7A contributors: mct/npt - updated : 20-12-2017
HGNC name zinc finger and BTB domain containing 7A
HGNC id 18078
Location 19p13.3      Physical location : 4.045.217 - 4.066.816
Genatlas name POZ and Krueppel erythroid myeloid ontogenic factor
Synonym name
  • leukemia/lymphoma-related factor
  • HIV:1 inducer of short transcripts binding factor 1
  • zinc finger and BTB domain containing 7
  • POK erythroid myeloid ontogenic factor
  • C2H2 zinc finger protein LRF
  • Factor binding IST-1
  • pokemon
  • lymphoma related factor
  • Synonym symbol(s) FBI1, LRF, ZBTB7, FBI-1, DKFZp547O146, MGC99631, ZNF857A, TIP21, pokemon
    DNA
    TYPE functioning gene
    STRUCTURE 23.64 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 6318 - 584 - 2002 12004059
    3 - 6482 - 584 - 2002 12004059
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemprostate  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • BTB/POZ-domain at its N terminus,
  • four C2H2-type zinc fingers
  • ten potential sumoylation sites located at lysines 61, 354, 371, 379, 383, 396, 486, 487, 536 and 539 (Roh 2007)
  • a POZ (poxvirus zinc finger) domain, as an NRE-binding protein
  • a Krüppel-like zinc finger at its C terminus (Jeon 2008)
  • HOMOLOGY
    interspecies ortholog to murine Zbtb7
    Homologene
    FAMILY
  • Krüppel c2h2-type zinc-finger protein family, POZ/BTB and Kruppel transcription factor family
  • POK family of transcriptional repressors
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation
  • BTB/POZ-domain Krüppel-like zinc-finger transcription factor acting as a proto-oncogenic protein, which represses tumor suppressor ARF gene transcription (Jeon 2008)
  • represses transcription of ADH5 and CDKN2A
  • can specifically stimulate Tat-activated HIV-1 transcription
  • represses the production of the tumor suppressor CDKN2A
  • may be an active participant in the differentiation process
  • plays an important role in adipogenesis, osteogenesis, oncogenesis, and transcription of NF-kB responsive genes (Roh 2007)
  • activity as a transcription factor may involve sumoylation, and sumoylation might be important in the regulation of transcription by ZBTB7A (Roh 2007)
  • may be involved in the transcriptional regulation of the genes involved in differentiation, cell cycle control, and tumor suppression, such as RB1 (Jeon 2008)
  • key transcriptional cascade for effective erythropoiesis, whereby GATA1 suppresses BCL2L11-mediated apoptosis via ZBTB7A
  • plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment
  • plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the germinal center (GC) response via distinct mechanisms
  • ZBTB7A, ZBTB7B pair are a core node of Th cell differentiation and function
  • is necessary for Hematopoietic stem cells (HSCs) maintenance by functioning as an erythroid-specific repressor of Delta-like 4 (DLL4) expression
  • novel tumor suppressor role of ZBTB7A in directly suppressing glycolysis.
  • plays an important role in oncogenic transformation and tumorigenesis
  • previously unrecognized role of ZBTB7A in negative regulation of melanoma metastasis, having important clinical implications
  • master oncogene crucial for the tumorigenicity and progression of a variety of cancers, demonstrated to enhance the proliferation and survival of hepatocellular carcinoma (HCC)
  • ZBTB7A was found to enhance the migration and invasion of HCC by increasing MEF2D expression
  • transcription factor ZBTB7A is important for haematopoietic lineage fate decisions and for regulation of glycolysis
  • is a potential modulator of breast cancer metastasis
  • functions as a tumor suppressor in gastric cancer cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+ binding
  • protein
  • binding to BCL6
  • bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation
  • interacting with RB1 through four GC-rich promoter elements (FREs) located at bp –308 to –188 of the RB promoter region (potently represses transcription of the RB1 gene, a tumor suppressor gene important in cell cycle arrest) ((Jeon 2008)
  • directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM
  • EPAS1 plays an indispensible role in SP1 transcription factor-mediated ZBTB7A induction, and participated in tumor cell survival and proliferation
  • is a new partner of SMAD4 and plays a negative role in TGFB1 pathway
  • ZBTB7A directly binds to the promoter and transcriptionally represses the expression of MCAM, establishing ZBTB7A as a bona fide transcriptional repressor of MCAM
  • ZBTB7A transcription factor occupies fetal HBG1 genes and maintains the nucleosome density necessary for HBG1 gene silencing in adults
  • ZBTB7A, ZBTB7B unlike in conventional T cells, functions in Tregs are not mediated by their repression of the transcription factor RUNX3
  • cell & other
    REGULATION
    induced by induced during the early phases of preadipocyte differentiation where it may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation
    Other upregulated during early phase of liver regeneration
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    aberrantly, in breast, lung, colon, prostate and bladder carcinomas
    tumoral germinal mutation      
    in acute myeloid leukaemia with t(8;21) translocation
    tumoral       loss of function
    loss-of-function mutation in ZBTB7A is a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a potential prognostic biomarker for breast cancer
  • Therapy target attractive therapeutic target for the treatment of many types of cancer
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    aberrantly, in breast, lung, colon, prostate and bladder carcinomas
    tumoral germinal mutation      
    in acute myeloid leukaemia with t(8;21) translocation
    tumoral       loss of function
    loss-of-function mutation in ZBTB7A is a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a potential prognostic biomarker for breast cancer
  • Therapy target attractive therapeutic target for the treatment of many types of cancer
    ANIMAL & CELL MODELS