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FLASH GENE
Symbol ZBTB5 contributors: mct/npt - updated : 04-11-2009
HGNC name zinc finger and BTB domain containing 5
HGNC id 23836
Location 9p13.2      Physical location : 37.438.101 - 37.465.407
Synonym name cDNA sequence, expressed in brain, >100kDa, related to murine Z13 protein
Synonym symbol(s) KIAA0354
DNA
TYPE functioning gene
STRUCTURE 27.30 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC392310 9 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) OR2S2 9p13.3-p13.1 olfactory receptor, family 2, subfamily S, member 2 LOC389719 9 hypothetical gene supported by M24070; NM_004559 LOC392311 9 similar to seven transmembrane helix receptor OR13C7P 9 olfactory receptor, family 13, subfamily C, member 7 pseudogene LOC392313 9 similar to olfactory receptor RECK 9p13-p12 reversion-inducing-cysteine-rich protein with kazal motifs C9orf19 9p12-p13 chromosome 9 open reading frame 19 CCIN 9p13-p12 calicin CLTA 9p13-p12 clathrin, light polypeptide (Lca) GNE 9p13-p12 clathrin, light polypeptide (Lca) LOC392314 9 similar to high mobility group protein homolog HMG4 RNF38 9p13-p12 ring finger protein 38 MRPS21P4 9p13.1 mitochondrial ribosomal protein S21 pseudogene 4 MELK 9p11.2 maternal embryonic leucine zipper kinase PAX5 9p13 paired box gene 5 (B-cell lineage specific activator protein) LOC389720 9 LOC389720 LOC392315 9 similar to 60S ribosomal protein L32 FLJ22611 GRHPR 9q11.2-q12 glyoxylate reductase/hydroxypyruvate reductase ZBTB5 9p13.1 zinc finger and BTB domain containing 5 LOC158237 9p13.1 similar to potassium channel tetramerisation domain containing 9 PAF53 9p13.1 RNA polymerase I associated factor 53 FBXO10 9p12 F-box only protein 10 LOC389721 9 similar to RAB1B, member RAS oncogene family; small GTP-binding protein FRMPD1 9p13.1 FERM and PDZ domain containing 1 FLJ31455 9p13.1 hypothetical protein FLJ31455 RRP40 9p11 exosome component Rrp40 MRPS10P5 9p12 exosome component Rrp40 MGC10765 9p13.1 hypothetical protein MGC10765 MCART1 9p13.3-p12 mitochondrial carrier triple repeat 1 SHB 9p12-p11 SHB (Src homology 2 domain containing) adaptor protein B ALDH1B1 9p13 aldehyde dehydrogenase 1 family, member B1 LOC347252 9p12 similar to bA113O24.1 (similar to insulin-like growth factor binding protein) LOC340501 9p12 similar to transcription elongation factor IIS - mouse LOC340502 9p12 similar to GAS2-related protein isoform beta FLJ35740 9p12 FLJ35740 protein LOC392316 9 similar to SNAG1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4654 74.15 677 - Gerhard (2004)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine   
Lymphoid/Immunetonsils   highly
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB/POZ domain
  • two C2H2-type zinc fingers
  • HOMOLOGY
    interspecies ortholog to murine Zbtb5
    Homologene
    FAMILY
  • kruppel family of C2H2-type zinc-finger proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localized to the nucleus, particularly nuclear speckles (Koh 2009)
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • may be an important transcription regulator of CDKN1A and may play a critical role in regulating important biological processes controlled by CDKN1A (Koh 2009)
  • recriuting corepressor-HDACs to deacetylate the histones of nearby nucleosomes around the proximal promoter (Koh 2009)
  • potently stimulates cell growth and increases the number of cells in S-phase and may be one of the major regulators of cell proliferation by regulating CDKN1A gene expression (Koh 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein binds to the proximal Sp1 binding GC box 5/6, which is a direct target of regulation by Sp1 and Sp family members (increases Sp1 binding to the proximal promoter region, which may explain transcription activation on the short proximal promoter) (Koh 2009)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with MYC in in B-cell lymphomas t(8;9)(q24;p13)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS