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FLASH GENE
Symbol ZBTB43 contributors: KTN - updated : 25-03-2008
HGNC name zinc finger and BTB domain containing 43
HGNC id 17908
Location 9q33-q34      Physical location : 129.567.284 - 129.600.485
Synonym name
  • related to ZID protein (zinc finger protein with interaction domain),82kDa
  • zinc finger protein 297B
  • zinc finger and BTB domain-containing protein 22B
  • Synonym symbol(s) KIAA0414, ZNF-X, ZNF297B, FLJ22470, ZBTB22B
    DNA
    TYPE functioning gene
    STRUCTURE 30.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2941 52 467 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveesophagus   predominantly
     intestine   moderately
     liver   highly
    Endocrineadrenal gland   moderately
     parathyroid   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
     female systemovary  highly
     male systemprostate   
     male systemtestis  moderately
    Respiratorylung   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    Muscularstriatumskeletal moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal BTB/POZ (pox virus and zinc finger domain) motif
  • three zinc finger motifs of the C2H2 type
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to dog ZBTB43 (98.7 pc)
    homolog to chimpanzee ZBTB43 (100 pc)
    homolog to rattus Zfp297b (91.7 pc)
    homolog to murine Zbtb43 (92.9 pc)
    intraspecies homolog to ZID protein (zinc finger protein with interaction domain)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • BDP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS