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FLASH GENE
Symbol ZBTB4 contributors: SGE - updated : 24-08-2009
HGNC name zinc finger and BTB domain containing 4
HGNC id 23847
Location 17p13.1      Physical location : 7.362.685 - 7.387.568
Synonym name KAISO-like zinc finger protein 1
Synonym symbol(s) KAISO-L1, KIAA1538
DNA
TYPE like-sequence
STRUCTURE 24.80 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 5961 - 1013 - -
4 - 5885 - 1013 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineparathyroid   highly
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB/POZ domain, POZ domain
  • 6 C2H2-type zinc fingers
  • Kaiso-like zinc fingers
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Zbtb4 (88.6pc)
    homolog to murine Zbtb4 (89.2pc)
    intraspecies homolog to ZBTB33
    Homologene
    FAMILY Kaiso-like proteins family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in transcriptional regulation
  • able to repress transcription in a methyl-dependent manner, yet their tissue-specific expression pattern suggests nonoverlapping functions
  • represses transcription of CDKN1A and controls the cellular response to TP53 activation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer or heterodimerizing with ZBTB38 (Filion 2006)
  • INTERACTION
    DNA bind methylated DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
  • protein
  • bind methylated CGCGs through its three Kruppel-like C2H2 zinc fingers
  • associates with the Sin3/histone deacetylase co-repressor and represses expression of CDKN1A as part of a heterodimeric complex with ZBTB17
  • shares with ZBTB33 the ability to bind both methylated DNA and the KBS (Kaiso binding site)
  • with CDKN1A may have critical oncogenic functions independent of the TP3 status of a cell
  • cell & other
    REGULATION
    Other phosphorylated by HIPK2 and down-regulated (Yamada 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in advanced stages of multiple tumours
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS