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FLASH GENE
Symbol ZBTB38 contributors: mct - updated : 28-06-2022
HGNC name zinc finger and BTB domain containing 38
HGNC id 26636
Location 3q23      Physical location : 141.043.054 - 141.168.625
Synonym name
  • zenon homolog
  • C-terminal binding protein)-interacting BTB (broad complex/tramtrack/bric-a-brac) zinc finger
  • protein phosphatase 1, regulatory subunit 171
    • Synonym symbol(s) FLJ22332, FLJ31131, FLJ35036, CIBZ, PPP1R171, ZNF921
    DNA
    TYPE functioning gene
    STRUCTURE 125.61 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 8413
    8 - 8108 - 1195 - 2019 30569128
    7 - 8010 - 1195 - 2019 30569128
    4 - 7798 - 1195 - 2019 30569128
    6 - 8096 - 1195 - 2019 30569128
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   highly
     parathyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • thirteen C2H2-type zinc fingers
  • Kaiso-like zinc fingers
  • two caspase-3 cleavage sites
  • a SP domain with two putative bipartite nuclear localization signals, at AA 845
    • 865 and 922
    940, and the second cleavage site DSTD situated between them
  • C-terminal Zinc finger of ZBTB38 can directly occupy promoters harboring the newly identified sequence motif in cell in a methyl-dependent manner and, depending on the gene context, contribute to modulating transcriptional response
    • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • zinc finger (ZF) family of methyl-CpG binding proteins
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a cardiac regulator and an effector of alpha1-adrenergic signaling
  • may be involved in the maintenance of panneuronal features and/or in the survival of mature neurons
  • able to repress transcription in a methyl-dependent manner, yet their tissue-specific expression pattern suggests non-overlapping functions
  • having a physiological function, participating in the negative regulation of apoptosis
  • promoted likely epithelial&
    • 8209;mesenchymal transition and the expression levels of genes downstream of the Wnt/CTNNB1 signaling pathway
  • may promote migration and invasive growth of bladder cancer cells via modulation of the Wnt/CTNNB1 signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA binding, bind methylated DNA
    RNA
    small molecule
    protein
  • binds to PE response elements (PERE) present in the promoter of genes such as NPPA and acts as a direct transcriptional activator of NPPA
  • also acts as a cofactor with GATA4, a key cardiac regulator
  • substrate for caspase-3
  • ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and they may use a mode of binding common to other zinc-finger proteins
  • E3 ubiquitin ligase RBBP6 ubiquitinates and destabilizes the transcriptional repressor ZBTB38, and this pathway ensures genome-wide DNA replication and chromosomal stability
  • deubiquitinase, USP9X interacts with ZBTB38, deubiquitinates it, and stabilizes it
  • ZBTB38 could repress cell migration and proliferation in prostate cancer via promoting DKK1 expression
  • ZBTB38 is essential for early embryonic development via the suppression of NANOG and SOX2 expression
    • cell & other
    REGULATION
    activated by activation of alpha1-adrenergic receptors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer tissues, which also strongly predicts a poorer prognosis of prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ZBTB38 is a potential prognosis marker for prostate cancer
    • Therapy target
    ANIMAL & CELL MODELS