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FLASH GENE
Symbol ZBTB33 contributors: mct - updated : 17-06-2015
HGNC name zinc finger and BTB domain containing 33
HGNC id 16682
Location Xq24      Physical location : 119.384.606 - 119.392.251
Synonym name
  • kaiso
  • kaiso transcription factor
    • Synonym symbol(s) ZNF348, ZNF-kaiso, KAiso
    DNA
    TYPE functioning gene
    STRUCTURE 7.64 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 5225 - 672 - Della Ragione (2006)
    2 - 5324 - 672 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousbrain   highly Homo sapiens
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal POZ/BTB domain
  • sequence-specific Kaiso binding sites (KBS)
  • three C-terminal zinc finger motifs of the C2H2 DNA-binding type
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Zbtb33
    homolog to xenopus Kaiso
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in regulation of transcription, DNA-dependent
  • behaving as a methylation-dependent transcriptional repressor
  • dual specific DNA-binding protein, functioning as a bimodal regulator of canonical Wnt signaling (Iioka 2009)
  • protein acting as a methyl-CpG binding protein by using three zinc-finger domains
  • bimodal transcription factor that recognizes methylated CpG dinucleotides or a conserved unmethylated sequence (TNGCAGGA, the Kaiso binding site)
  • may possess bimodal activity with regards to its regulation of gene expression (Iioka 2009)
  • dual-specificity POZ-ZF transcription factor that regulates gene expression by binding to sequence-specific Kaiso binding sites (KBS) or methyl-CpG dinucleotide pairs
  • Cys(2)His(2) zinc finger (ZF) protein that mediates methyl-CpG-dependent and sequence-specific transcriptional repression
  • bifunctional Cys(2)His(2) zinc finger protein implicated in tumor-cell proliferation, binds to both methylated CpG (mCpG) sites and a specific nonmethylated DNA motif (TCCTGCNA) and represses transcription by recruiting chromatin remodeling corepression machinery to target genes
  • methylated DNA-binding protein and a transcription repressor interacting with the corepressor protein complex NCoR
  • is a key regulator of spleen germinal center formation by repressing BCL6 expression in splenocytes
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • intracellular signaling cascade
    • a component homodimerized via its POZ domain
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • specific binding partner for the Armadillo catenin and cell adhesion cofactor CTNND1 (Spring 2005) which positively regulate rapsyn expression (Iioka 2009)
  • specific binding partner of CTCF (interaction occurs through a C-terminal region of CTCF and the POZ domain of ZBTB33, interaction that negatively regulates CTCF insulator activity)
  • interacts with the the N-CoR (nuclear receptor corepressor 1) protein through its POZ/BTB domain (Iioka 2009)
  • can regulate LEF1-activity for these effects via modulating HDAC1 and CTNND1-complex formation (Iioka 2009)
  • dual-specificity POZ-ZF transcription factor that regulates gene expression by binding to sequence-specific Kaiso binding sites (KBS) or methyl-CpG dinucleotide pairs
  • ZNF131 is a ZBTB33-specific binding partner
  • when released from CDH1 by WNT3A-stimulated phosphorylation, CTNND1 controls the activity of the ZBTB33 transcriptional factor, enhancing its binding to repressed promoters and relieving its inhibition of the CTNNB-TCF-4 transcriptional complex
  • binds to highly active promoters that are marked with high levels of acetylated histones
  • stage-specific co-regulators ZBTB33 and SOX10 sequentially interact with TCF7L2 to coordinate the switch at the transitions of differentiation initiation and maturation during oligodendrocyte development
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for X-linked mental retardation disorders
    Marker
  • cytoplasmic CTNND1, cytoplasmic ZBTB33, and nuclear MTA2 expression correlated directly with histological type and Masaoka stage and may thus be used as potential biomarkers to predict biological behavior of thymoma
    • Therapy target
    ANIMAL & CELL MODELS