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FLASH GENE
Symbol ZBTB22 contributors: KTN - updated : 21-03-2008
HGNC name zinc finger and BTB domain containing 22
HGNC id 13085
Location 6p21.3      Physical location : 4.514.428 - 33.285.719
Synonym name
  • zinc finger protein 297
  • protein BING1
  • Synonym symbol(s) TAFII32, BING1, ZNF297, ZBTB22A, ZNF297A, fruitless, fru
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster including tapasin, DAXX, RGL2, HKE2
    STRUCTURE 3.00 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located at the centromeric end of MHC region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2647 65 634 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestine   moderately
     pancreas exocrine   moderately
     pharynx   predominantly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix moderately
    Respiratorylung   highly
    Skin/Tegumentskin   moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion moderately in Lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal POZ/BTB domain
  • three C terminal zinc finger C2H2 type motifs
  • conjugated MetalloP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to dog ZBTB22 (93.7 pc)
    homolog to chimpanzee ZBTB22 (99.7 pc)
    homolog to rattus Zfp297 (87.1 pc)
    homolog to murine Zbtb22 (87.6 pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional regulator
  • acting as a retinoid-X receptor
  • acting as a thyroid hormone receptor coactivator
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • thyroid hormone receptor
  • cell & other
  • retinoic acid receptor
  • vitamin D receptor
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS