Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZBTB21 contributors: mct - updated : 09-05-2023
HGNC name zinc finger and BTB domain containing 21
HGNC id 13083
Location 21q22.3      Physical location : -
Synonym name
  • zinc finger protein 295
  • Synonym symbol(s) KIAA1227, novel, ZNF295, DKFZp781N1974
    DNA
    TYPE functioning gene
    STRUCTURE 23.53 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 6784 - 865 - 2005 15629158
  • ZNF295S
  • 5 zinc finger domains
  • could interact not only with themselves and each other, but also with another POK protein ZFP161 known to function as a transcription repressor and an activator
  • 2 - 7687 - 1066 - 2005 15629158
  • 9 zinc finger domains
  • could interact not only with themselves and each other, but also with another POK protein ZFP161 known to function as a transcription repressor and an activator
  • 4 splicing 6849 - 865 - 2005 15629158
    isoform S
    4 - 7606 - 1066 - 2005 15629158
    isoform L
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
    Lymphoid/Immunethymus    
    Respiratoryrespiratory tracttrachea   
    Urinarykidney   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal BTB-POZ domain
  • 13 C2H2-type zinc fingers
  • a KRAB domain
  • two separate regions for repression activity : the BTB/POZ domain and the central region between BTB/POZ and ZF domains
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY zinc finger protein family C2H2 Krüppel type
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration
  • may be involved in the bi-directional control of gene expression in concert with ZBTB14
  • with RIPK4, ZBTB21 has potential role in the pathogenesis of Congenital heart defect (CHD) in Down syndrome (DS)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS