basic FUNCTION
| involved in transcriptional regulation |
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activates the transcription of BCL2 |
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represses the expression of many genes in response to DNA damage in an Akt- and YWHAH-regulated manner |
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required for the recruitment of a fraction of TOPBP1 to chromatin, for the protection of TOPBP1 from proteasomal degradation and for ATR-dependent signal transduction |
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implicated in the control of keratinocyte proliferation and in the cellular response to TGFbeta |
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involved in controlling proliferation and differentiation in hair follicles and in hair fiber morphogenesis |
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selectively suppresses TNFA-induced JNK1 activation and cell death independently of its transcription activity |
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acts as a signal- and pathway-specific modulator or regulator that specifically regulates TNFA-induced JNK1 activation and cell death |
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is a direct activator of WIF1 transcriptional activity, which is found at WIF1 promoter |
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BTB/POZ domain containing transcription factor that can function as an activator or repressor depending on its binding partners |
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new functions for ZBTB17 in the heart, a transcription factor that may play a role as a novel cardiomyopathy gene |
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ZBTB17 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation |
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ZBTB17 is an essential transcriptional activator of AMELX, which is critical in odontogenesis and matrix mineralization in the developing tooth |