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FLASH GENE
Symbol ZBTB17 contributors: mct - updated : 22-01-2010
HGNC name zinc finger protein 151 (pHZ-67)
HGNC id 12936
Location 1p36.1      Physical location : 16.268.365 - 16.302.627
Synonym name
  • Myc-interacting Zn finger protein-1
  • zinc finger protein 151
  • zinc finger protein 60
  • Myc-binding transcription factor
  • signal- and pathway-specific modulator or regulator
  • Synonym symbol(s) MIZ1, ZNF151, pHZ-67, MIZ-1, ZNF60, SMOR
    DNA
    TYPE functioning gene
    STRUCTURE 34.26 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2767 87 803 - 2009 19815509
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Reproductivefemale systemovary  highly
    Skin/Tegumentskin    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum basale 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger motifs, C2H2 type, Krüppel-like
  • N-terminal POZ protein-protein interaction domain, which can mediate both homo- and heterodimerization among POZ domain proteins
  • and which is required for its transcriptional activation and repression activity
  • 13 zinc fingers
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • poxvirus and zinc-finger (POZ) domain/zinc-finger transcription factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text localizes in both the cytoplasm and the nucleus (Liu 2009)
    basic FUNCTION
  • involved in transcriptional regulation
  • activates the transcription of BCL2
  • represses the expression of many genes in response to DNA damage in an Akt- and YWHAH-regulated manner
  • required for the recruitment of a fraction of TOPBP1 to chromatin, for the protection of TOPBP1 from proteasomal degradation and for ATR-dependent signal transduction
  • implicated in the control of keratinocyte proliferation and in the cellular response to TGFbeta
  • involved in controlling proliferation and differentiation in hair follicles and in hair fiber morphogenesis
  • selectively suppresses TNFA-induced JNK1 activation and cell death independently of its transcription activity
  • acts as a signal- and pathway-specific modulator or regulator that specifically regulates TNFA-induced JNK1 activation and cell death
  • is a direct activator of WIF1 transcriptional activity, which is found at WIF1 promoter
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    c-MYC/ZBTB17/BCL2 pathway (repression of ZBTB17-driven BCL2 transcription defines a previously unknown genetic pathway linking c-MYC to apoptosis)
    a component
  • heterodimerizes with BCL6 to suppress expression of CDKN1A during the class switching of immunoglobulin genes in B cells
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with BCL2 (inhibition of the ZBTB17/BCL2 signal is an essential event during the apoptotic response)
  • inetraction with MYC (affect the activity of the ATR checkpoint through their effect on TOPBP1 chromatin)association and stability
  • MYC, ZBTB17 and MAX are associated with the CEBPD promoter in proliferating cells, when CEBPD expression is repressed
  • binding of Myc to ZBTB17 is required to antagonize growth suppression and induction of senescence by TGFbeta
  • cell & other
    REGULATION
    inhibited by YWHAH
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    is dispensable for c-Myc-induced cell cycle progression and transformation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS