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FLASH GENE
Symbol ZBED6 contributors: mct - updated : 18-03-2014
HGNC name zinc finger, BED-type containing 6
HGNC id 33273
Location 1q32.1      Physical location : 203.766.650 - 203.769.588
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
text
  • located in one of the first introns of another gene, zinc finger CCCH-type containing 11A (ZC3H11A), and ZBED6 coding sequence is located in intron 2 of ZC3H11A 6)
  • STRUCTURE 2.94 kb     1 Exon(s)
    text structure
  • intron-less
  • binding sites were mainly found in CpG islands (88p100) with a preference for locations immediately downstream of transcription start site (TSS) 6)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2940 109.8 979 mainly localized to the nuclear fraction 2013 24043816
  • ZBED6l
  • role of nuclear ZBED6 as an inhibitor of functional beta cell differentiation and as an activator of the cell cycle
  • - - - 95 - cytosolic 2013 24043816
  • lacked N-terminal peptide sequences
  • truncated ZBED6 protein may participate in cytoplasmic functions of the fully mature and nonproliferating beta cell
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreasislet of Langerhans    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Muscularmyoblast Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two DNA-binding BED domains and one hobo-Ac-Tam3 (hATC) dimerization domain in its N-terminal half
  • a bipartite nuclear localization signal
  • a putative nucleolar localization signal
  • HOMOLOGY
    Homologene
    FAMILY CCCH zinc-finger BEAT and DREF (BED) domain-containing family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • important transcription factor in placental mammals, affecting development, cell proliferation, and growth
  • ZBED6 does not play a major role in preadipocyte differentiation
  • may be that ZBED6 acts as a repressor of these genes in non-beta cells and that ZBED6 binding to the same genes is abolished in beta cells
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • bound the genes of the beta cell transcription factors NEUROG3 and NEUROD2 in muscle cells, but not in islet cells
  • ZBED6 target gene IGF2 (ZBED6 acts as an IGF2 repressor)
  • ZBED6 binding to the MAFA gene was found in myoblasts, but was not presently observed in human islet cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS