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FLASH GENE
Symbol ZBED4 contributors: shn/npt - updated : 06-05-2012
HGNC name zinc finger, BED domain containing 4
HGNC id 20721
Location 22q13.33      Physical location : 50.247.496 - 50.283.726
Synonym name zinc finger BED domain-containing protein 4
zinc finger, BED domain containing 4
Synonym symbol(s) KIAA0637
DNA
TYPE functioning gene
STRUCTURE 36.23 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
Map cen - D22S922 - D22S1169 - ZBED4 - qter
Physical map
LOC150400 22q13.33 similar to 60S ribosomal protein L35 LOC391339 22 similar to erythrocyte membrane-associated giant protein antigen 332 LOC391340 22 similar to vitelline envelope sperm lysin receptor LOC388917 22 LOC388917 LOC348645 22q13.33 hypothetical protein LOC348645 BRD1 22q13.33 bromodomain containing 1 ZBED4 22q13.33 zinc finger, BED domain containing 4 ALG12 22q13.3 zinc finger, BED domain containing 4 MGC11256 22p13 hypothetical protein MGC11256 LOC164714 22q13.33 similar to RIKEN cDNA 1700019P01 MLC1 22q13.33 megalencephalic leukoencephalopathy with subcortical cysts 1 MOV10L1 22q13.33 Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) PANX2 22q13.33 pannexin 2 PP2447 22q13.33 hypothetical protein PP2447 SELO 22q13.33 selenoprotein O TUBGCP6 22q13.31-q13.33 tubulin, gamma complex associated protein 6 HDAC10 22q13.31 histone deacetylase 10 MAPK12 22q13.33 mitogen-activated protein kinase 12 MAPK11 22q13.33 mitogen-activated protein kinase 11 PLXNB2 22q13.31-q13.33 plexin B2 KIAA0685 22q13.3 plexin B2 SBF1 22q13.33 SET binding factor 1 FLJ21135 ALDRL6 22q13.3 aldehyde reductase (aldose reductase) like 6 BC002942 22q13.33 hypothetical protein BC002942 384D8-2 22q13.33 hypothetical protein 384D8_6 SCO2 22q13.33 SCO cytochrome oxidase deficient homolog 2 (yeast) ECGF1 22q13.3 endothelial cell growth factor 1 (platelet-derived)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 6897 135 1171 cone nuclei, inner segments and pedicles and Müller cell endfeet in the retina Ishikawa et al, 1998
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina  specific Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
VisualMuller cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four predicted DNA-binding domains
  • a dimerization domain
  • four BED zinc finger domains
  • hACT dimerization domain
  • and two LXXLL motifs characteristic of coactivators/corepressors of nuclear hormone receptors
  • mono polymer dimer
    HOMOLOGY
    interspecies ortholog to ZBED4 , Mus musculus
    ortholog to zbed4, Danio rerio
    ortholog to Zbed4, Rattus norvegicus
    Homologene
    FAMILY
  • human hAT transposase family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION a possible involvement in retinal morphogenesis and Müller cell function (
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • a candidate gene for patients affected with cone dystrophies
  • Marker
    Therapy target
    ANIMAL & CELL MODELS