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FLASH GENE
Symbol ZAR1 contributors: mct/npt - updated : 31-03-2010
HGNC name zygote arrest 1
HGNC id 20436
Location 4p11      Physical location : 48.492.308 - 48.496.420
Synonym name oocyte-specific maternal effect factor
DNA
TYPE functioning gene
STRUCTURE 4.11 kb     4 Exon(s)    single Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ39576 4p13 hypothetical protein FLJ39576 FLJ13220 4p13 hypothetical protein FLJ13220 GNPDA2 4p13 glucosamine-6-phosphate deaminase 2 LOC391648 4 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 GABRG1 4p14-q21.1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 GABRA2 4p13-p12 gamma-aminobutyric acid (GABA) A receptor, alpha 2 LOC256000 4p13 similar to ras-related C3 botulinum toxin substrate 1 isoform Rac1; rho family, small GTP binding protein Rac1 COX7B2 4p13 cytochrome c oxidase subunit VIIb2 GABRA4 4p14-p12 gamma-aminobutyric acid (GABA) A receptor, alpha 4 GABRB1 4p13-p12 gamma-aminobutyric acid (GABA) A receptor, beta 1 FLJ20502 4p12 hypothetical protein FLJ20502 ATP10D 4p13-q13.1 ATPase, Class V, type 10D CRN 4p13-p12 corin HOZFP 4p12 ovarian zinc finger protein CNGA1 4p14-q13 cyclic nucleotide gated channel alpha 1 LOC152519 4p12 hypothetical protein LOC152519 TXK 4p12 TXK tyrosine kinase TEC 4p12 tec protein tyrosine kinase KIAA1458 4p12 KIAA1458 protein SLC10A4 4p12 solute carrier family 10 (sodium/bile acid cotransporter family), member 4 ZAR1 4p11 zygote arrest 1 KIAA0826 4p12 KIAA0826 protein OCIA 4q11 KIAA0826 protein MGC45416 4p12 hypothetical protein MGC45416 FLJ21511 4p12 hypothetical protein FLJ21511 LOC391649 4 similar to SNAG1 LOC391650 4 similar to SNAG1 LOC391651 4 similar to SNAG1 LOC391652 4 similar to SNAG1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1438 - 424 - Uzbekova (2006)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text early embryon
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal PHD motif
  • atypical plant homeobox zing finger domain, suggesting its role in transcription regulation (Uzbekova 2006)
  • HOMOLOGY
    interspecies homolog to murine Zar1
    Homologene
    FAMILY
  • ZAR1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning at the oocyte-to-gamete transition with key role for the initiation of embryogenesis (Wu 2003)
  • ovary-specific maternal factor that plays essential roles during the oocyte-to-embryo transition (Wu 2003)
  • ZAR1 could also be implicated in the regulation of meiosis and post meiotic differentiation of male and female germ cells (Uzbekova 2006)
  • central role in early reproductive processes (Uzbekova 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS