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FLASH GENE
Symbol YY1AP1 contributors: mct - updated : 28-02-2017
HGNC name YY1 associated protein 1
HGNC id 30935
Corresponding disease
AHBBD arterial occlusive disease, progressive, heart defect, bone fragility, brachysyndactyly
Location 1q21.3      Physical location : 155.629.233 - 155.658.791
Synonym name
  • hepatocellular carcinoma susceptibility protein
  • YY1 associated protein
  • Synonym symbol(s) HCCA2, FLJ10875, FLJ13914, YAP, GRNG, HCCA1, YY1AP
    DNA
    TYPE functioning gene
    STRUCTURE 29.00 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 2833 81.7 739 - 2004 14744866
    11 splicing 2676 87.9 796 - 2004 14744866
    11 splicing 2749 - 750 - 2004 14744866
    - splicing 2529 50.7 467 - 2004 14744866
    11 splicing 2705 75.3 684 - 2004 14744866
    13 - 2756 - 424 - 2004 14744866
    10 - 2604 - 750 - 2004 14744866
    11 - 2695 - 730 - 2004 14744866
    10 - 2714 - 739 - 2004 14744866
    10 - 2571 - 750 - 2004 14744866
    10 - 3031 - 868 - 2004 14744866
    10 - 3091 - 888 - 2004 14744866
    7 - 2778 - 739 - 2004 14744866
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  highly Homo sapiens
    cell lineage
    cell lines hepatocellular carcinoma cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two SH3 binding domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • localizes to the nucleus, and in the nucleolus
  • basic FUNCTION
  • may be playing a role in a cascade of intracellular signal transduction because the protein was characterized with two Src homology 3 (SH3) binding-domains and several functional motifs of phosphorylation
  • playing key roles in the control of TBX5-dependent transcription and suggest its involvement in cardiac and limb development
  • may play a novel role in cell cycle regulation
  • its expression promotes hepatocellular carcinoma cell proliferation and is required for the maintenance of stem cell features
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is a component of the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to YY1 protein
  • interacting with TAZ (TAZ-related protein with conserved functional domains, also stimulates TBX5-dependent transcription, possibly by forming a heterodimer with TAZ)
  • YY1AP1 is a novel co-activator of YY1
  • YY1AP1-interacting protein, is MAD2L2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AHBBD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma with invasion of tumour capsule
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS