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Symbol YWHAZ contributors: mct/npt/pgu - updated : 27-01-2016
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
HGNC id 12855
Location 8q22.3      Physical location : 101.930.803 - 101.965.623
Synonym name
  • 14-3-3 zeta protein
  • phospholipase A2
  • protein kinase C inhibitor protein 1
  • 14-3-3 protein/cytosolic phospholipase A2
  • Synonym symbol(s) KCIP-1, 14-3-3-zeta, MGC126532, MGC138156, MGC111427, HEL-S-3, HEL-S-93, HEL4, YWHAD
    TYPE functioning gene
    STRUCTURE 34.82 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RPL30 8q22-q24 ribosomal protein L30 FLJ39553 8q22.2 hypothetical protein FLJ39553 UK114 8q22 hypothetical protein FLJ39553 POP1 8q22.1 processing of precursors 1 FLJ13955 8q22.2 hypothetical protein FLJ13955 KCNS2 8q23.3-q24.11 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 STK3 8q22.2 serine/threonine kinase 3 (STE20 homolog, yeast) MRP63P7 8q22.2 mitochondrial ribosomal protein 63 pseudogene 7 OSR2 8q22.2 odd-skipped-related 2A protein COH1 8q22.2 Cohen syndrome 1 COX6C 8q22-q23 cytochrome c oxidase subunit VIc DKFZP434I092 8q22.3 DKFZP434I092 protein LOC286151 8q22.3 similar to RIKEN cDNA 4930533G20 POLR2K 8q22 polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa SPAG1 8q22 sperm associated antigen 1 RNF19 8q22 ring finger protein 19 LOC157567 8q22.3 hypothetical protein LOC157567 MGC39715 8q22.3 hypothetical protein MGC39715 PABPC1 8q22.2-q23 poly(A) binding protein, cytoplasmic 1 LOC392256 YWHAZ 2p25.2-p25.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide LOC51123 8q22.3 HSPC038 protein FKSG17 8q22.3 HSPC038 protein TFCP2L3 8q22.3 HSPC038 protein NCALD 8q22-q23 neurocalcin delta LOC392257 8 similar to IAP-associated factor VIAF1; phosducin-like 2 RRM2B 8q23.1 ribonucleotide reductase M2 B (TP53 inducible) DD5 8q22 ribonucleotide reductase M2 B (TP53 inducible) ODF1 8q22.3 outer dense fiber of sperm tails 1 TIEG 8q22.2 TGFB inducible early growth response OAZIN 8q22.3 ornithine decarboxylase antizyme inhibitor LOC389679 8 similar to hypothetical protein ATP6V1C1 8q22.3 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1 LOC389680 8 similar to MGC39526 protein BAALC 8q22.3 brain and acute leukemia, cytoplasmic FZD6 8q22.3-q23.1 frizzled homolog 6 (Drosophila) CTHRC1 8q22.3 collagen triple helix repeat containing 1 MFTC 8q22.3 mitochondrial folate transporter/carrier DKFZP564O0463 8q22.3 DKFZP564O0463 protein TARBP2P 8q22-q24 TAR (HIV) RNA binding protein 2 pseudogene
    TRANSCRIPTS type messenger
    text all transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 3003 27 245 - 2004 15225635
  • variant 1
  • containing a different 5' UTR compared to variant 2
  • both variants encode the same protein, however, they are differentially expressed in hematopoietic cells
  • 6 splicing 3077 27 245 - 2004 15225635
  • variant 2
  • using a different exon in the 5' UTR compared to variant 1
  • both variants encode the same protein, however, they are differentially expressed in hematopoietic cells
  • 6 - 3042 - 245 - 2004 15225635
    variant 6
    6 - 3023 - 245 - 2004 15225635
    variant 5
    6 - 2974 - 245 - 2004 15225635
    variant 4
    6 - 3020 - 245 - 2004 15225635
    variant 3
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     mouthtongue (see gustatory)  highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis   
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    Visualeyeanterior segmentcornea  
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    at STAGE
  • 14-3-3 family
  • CATEGORY regulatory , protooncogene
    basic FUNCTION
  • multifunctional regulator involved in cell-cyle control (checkpoint) cellular proliferation and apoptosis by binding and sequestering phosphoserine containing proteins and by inhibiting the activation of p38 MAP kinase
  • playing a role in in EGF receptor signaling or regulation
  • forms a molecular complex with HSPD1 and PRNP in the CNS under physiological conditions and this complex might become disintegrated in the pathologic process of prion diseases
  • candidate proto-oncogene and may have a role in head and neck squamous cell carcinoma.carcinogenesis
  • antiapoptotic protein
  • YWHAZ controls PCYT1A nuclear import in response to calcium signals, thereby regulating mammalian phospholipid synthesis
  • YWHAZ and possibly other 14-3-3 isoforms may have additional functional roles conducted by the monomeric state
  • has a role in the fibrillization of MAPT in Alzheimer brain, and MAPT phosphorylation does not affect YWHAZ-induced MAPT aggregation
  • essential role for YWHAZ in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of CORO1A
  • CELLULAR PROCESS cell life, antiapoptosis
    a component
  • HDAC7 directly binds to beta-catenin and forms a complex with YWHAE, YWHAZ, and YWHAH proteins
  • novel function of YWHAZ/CTNNB1 axis in promoting epithelial-mesenchymal transition and lung cancer metastasis
    small molecule
  • IL9R alpha chain
  • p38 MAP kinase
  • tuberin/14-3-3zeta interaction is regulated by Akt-mediated phosphorylation of tuberin
  • EGF receptor interacting protein
  • interaction with YWHAB, YWHAE, YWHAH, ATXN1 mediated by AKT1 to modulate the neurotoxicity of SCA1
  • interacting with ADAM22,(can regulate cell adhesion and spreading, therefore it has a potential role in neural development and function)
  • interacts with nuclear localization sequence of forkhead transcription factor FOXO4
  • interaction between CENPJ and 14-3-3, and this interaction appears to be phosphorylation and cell cycle dependent
  • YWHAZ-KH1 interaction regulates the mRNA-decay activity of KHSRP by sequestering the protein in a separate functional pool
  • PCYT1A nuclear import was associated with binding to YWHAZ, a key regulator of protein trafficking
  • monomeric form interacts with MAPT and with the HSPB6 protein
  • YWHAZ is a direct binding partner of GNB2L1
  • interacts physically with STAT3 and regulates its constitutive activation in multiple myeloma cells (
  • may be an endogenous physiologic regulator of HNF1A
  • binds to PPP1CA and causes its retention in the cytosol which suggests that YWHAZ regulates nuclear trafficking of PPP1CA in mammalian cells
  • binding of AXL to YWHAZ, which is essentially required for AXL-mediated cell invasion, transendothelial migration, and resistance against TGFB1
  • cell & other
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    tumoral     --over  
    contribute to de novo chemoresistance to anthracyclines and are permissive for metastatic recurrence
    constitutional     --over  
    protects cells from drug-induced apoptosis
    Variant & Polymorphism
    Candidate gene
  • YWHAZ driven contextual changes of Smad partners from TP53 to GLI2 may serve as biomarkers and therapeutic targets of TGFB1-mediated cancer progression
  • Therapy target
  • locomotor hyperactivity in Ywhaz KO mice is associated with dopamine transporter dysfunction
  • deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating