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FLASH GENE
Symbol YWHAB contributors: mct/ - updated : 26-06-2014
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HGNC id 12849
Location 20q13.12      Physical location : 43.514.343 - 43.537.160
Synonym name
  • 14-3-3 beta protein
  • KCIP protein kinase inhibitor
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
  • protein 1054
  • Synonym symbol(s) HS1, 14-3-3-beta, KCIP-1, GW128, YWHAA, 14-3-3 alpha
    DNA
    TYPE functioning gene
    STRUCTURE 22.82 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    JPH2 20q12-q13.1 junctophilin 2 C20orf111 20q13.11 chromosome 20 open reading frame 111 GDAP1L1 20q12 ganglioside-induced differentiation-associated protein 1-like 1 C20orf142 20q13.12 chromosome 20 open reading frame 142 R3HDML 20 R3H domain (binds single-stranded nucleic acids) containing-like FLJ39654 20q13.12 hypothetical protein FLJ39654 LOC149704 20q13.12 hypothetical LOC149704 HNF4A 20q12-q13.1 hepatocyte nuclear factor 4, alpha RPL37AP1 20q12 ribosomal protein L37a pseudogene 1 C20orf121 20q13.11 chromosome 20 open reading frame 121 TDE1 20q13.1-q13.3 tumor differentially expressed 1 PKIG 20q13.2-q13.13 protein kinase (cAMP-dependent, catalytic) inhibitor gamma ADA 20q12 adenosine deaminase MGC5566 20q13.12 hypothetical protein MGC5566 WISP2 20q12-q13.1 WNT1 inducible signaling pathway protein 2 KCNK15 20q12-q13 potassium channel, subfamily K, member 15 RIMS4 20 regulating synaptic membrane exocytosis 4 LOC391252 20 similar to piggyBac transposable element derived 4 YWHAB 20q13.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide LOC200226 20q13.12 similar to Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (PABP 2) TOMM34 20q12-q13.11 translocase of outer mitochondrial membrane 34 STK4 20q11.2-q13.2 serine/threonine kinase 4 KCNS1 20q12 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 WFDC5 20q13.11 WAP four-disulfide core domain 5 WFDC12 20q12-q13.1 WAP four-disulfide core domain 12 PI3 20q12-q13 protease inhibitor 3, skin-derived (SKALP) SEMG1 20q13.1 semenogelin I SEMG2 20q13.1 semenogelin II LOC149709 20q13.12 similar to RIKEN cDNA 1700049M11 SLPI 20q12-q13.2 secretory leukocyte protease inhibitor (antileukoproteinase) MATN4 20q13.1-q13.2 matrilin 4 RBPSUHL 20q12-q13.1 recombining binding protein suppressor of hairless (Drosophila)-like SDC4 20q13.1 syndecan 4 (amphiglycan, ryudocan) C20orf35 20q13.12 chromosome 20 open reading frame 35 C20orf10 20q12-13.12 chromosome 20 open reading frame 10 PIGT 20q12-q13.1 phosphatidyl inositol glycan class T LOC149710 20q13.12 hypothetical LOC149710 WFDC2 20q12-q13.2 WAP four-disulfide core domain 2 WFDC6 20q13.12 WAP four-disulfide core domain 6 SPINLW1 20q12-q13.2 serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin) WFDC8 20q13.12 WAP four-disulfide core domain 8 WFDC9 20q12-q13.1 WAP four-disulfide core domain 9 WFDC10A 20q13.12 WAP four-disulfide core domain 10A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3110 28 246 - 2001 11313964
  • encoding the same protein tahn variant 2
  • 7 exons
  • 6 splicing 3015 28 246 - 2001 11313964
  • lacking an exon in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • 6 exons
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     salivary gland   highly
    Endocrineparathyroid   moderately
     thyroid   moderately
    Hearing/Equilibriumear   predominantly
    Lymphoid/Immunetonsils   highly
    Nervousnervespinal nerve   
    Reproductivefemale systembreastmammary gland moderately
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ywhab
    ortholog to rattus Ywhab (98.4pc)
    intraspecies homolog to ywhaz
    Homologene
    FAMILY
  • 14.3.3 family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text perinuclear region
    basic FUNCTION
  • inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
  • multifunctional regulator
  • activating protein kinase C, multifunctional regulator of the cell signaling processes mediated by both kinases
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
  • 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs and molecules such as Raf, BAD and Cbl
  • AKIRIN2-YWHAB complex could act as a transcriptional silencer, and MAPK1 was one of the target genes of the AKIRIN2-YWHAB complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38 MAP kinase
  • ITGB1 for regulation of integrin-mediated cell adhesion and signaling events
  • the TSC1-TSC2 complex and negatively regulate the function of the TSC proteins
  • SSH1
  • interaction with ATXN1, YWHAE, YWHAH, YWHAZ mediated by AKT1 to modulate the neurotoxicity of SCA1
  • interacting with AKIRIN2
  • phosphorylation-dependent interaction between YWHAB and SPTAN1 acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM
  • interacts with DACT1 (YWHAB binding attenuates the ability of hDpr1 to promote Dishevelled (Dvl) degradation, thus enhancing Wnt signaling)
  • YWHAB binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum
  • YWHAB is absolutely required for KCNK3 internalization, a role heretofore not described for a 14-3-3 protein
  • interactors of GCGR, LDLR and TMED2, significantly enhanced glucagon-stimulated glucose production, while YWHAB inhibited glucose production
  • interaction of DAPK2 with ACTN1 was localized at the plasma membrane, resulting in massive membrane blebbing and reduced cellular motility, whereas the interaction of DAPK2 with YWHAB was localized to the cytoplasm, with no impact on blebbing, motility, or viability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • has the potential to be used as a diagnostic and prognostic biomarker in gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS