Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol YWHAB contributors: mct/ - updated : 26-06-2015
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HGNC id 12849
Location 20q13.12      Physical location : 43.514.343 - 43.537.160
Synonym name
  • 14-3-3 beta protein
  • KCIP protein kinase inhibitor
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
  • protein 1054
  • Synonym symbol(s) HS1, 14-3-3-beta, KCIP-1, GW128, YWHAA, 14-3-3 alpha
    DNA
    TYPE functioning gene
    STRUCTURE 22.82 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3110 28 246 - 2001 11313964
  • encoding the same protein tahn variant 2
  • 7 exons
  • 6 splicing 3015 28 246 - 2001 11313964
  • lacking an exon in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • 6 exons
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     salivary gland   highly
    Endocrineparathyroid   moderately
     thyroid   moderately
    Hearing/Equilibriumear   predominantly
    Lymphoid/Immunetonsils   highly
    Nervousnervespinal nerve   
    Reproductivefemale systembreastmammary gland moderately
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ywhab
    ortholog to rattus Ywhab (98.4pc)
    intraspecies homolog to ywhaz
    Homologene
    FAMILY
  • 14.3.3 family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text perinuclear region
    basic FUNCTION
  • inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
  • multifunctional regulator
  • activating protein kinase C, multifunctional regulator of the cell signaling processes mediated by both kinases
  • enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), regulates the pace of the circadian clock
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
  • 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs and molecules such as Raf, BAD and Cbl
  • AKIRIN2-YWHAB complex could act as a transcriptional silencer, and MAPK1 was one of the target genes of the AKIRIN2-YWHAB complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38 MAP kinase
  • ITGB1 for regulation of integrin-mediated cell adhesion and signaling events
  • the TSC1-TSC2 complex and negatively regulate the function of the TSC proteins
  • SSH1
  • interaction with ATXN1, YWHAE, YWHAH, YWHAZ mediated by AKT1 to modulate the neurotoxicity of SCA1
  • interacting with AKIRIN2
  • phosphorylation-dependent interaction between YWHAB and SPTAN1 acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM
  • interacts with DACT1 (YWHAB binding attenuates the ability of hDpr1 to promote Dishevelled (Dvl) degradation, thus enhancing Wnt signaling)
  • YWHAB binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum
  • YWHAB is absolutely required for KCNK3 internalization, a role heretofore not described for a 14-3-3 protein
  • interactors of GCGR, LDLR and TMED2, significantly enhanced glucagon-stimulated glucose production, while YWHAB inhibited glucose production
  • interaction of DAPK2 with ACTN1 was localized at the plasma membrane, resulting in massive membrane blebbing and reduced cellular motility, whereas the interaction of DAPK2 with YWHAB was localized to the cytoplasm, with no impact on blebbing, motility, or viability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • has the potential to be used as a diagnostic and prognostic biomarker in gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS